| Автор | Post, Steven R. |
| Автор | Hammond, H. Kirk |
| Автор | Insel, Paul A. |
| Дата выпуска | 1999 |
| dc.description | ▪ Abstract Cardiac β-adrenergic receptors, which respond to neuronally released and circulating catecholamines, are important regulators of cardiac function. Congestive heart failure, a common clinical condition, is associated with a number of alterations in the activation and deactivation of β-adrenergic receptor pathways. Studies with failing hearts from humans and animals indicate that such alterations include changes in the expression or function of β-adrenergic receptors, G-proteins, adenylyl cyclases, and G-protein receptor kinases. The net effect of these alterations is the substantial blunting of β-adrenergic receptor-mediated cardiac response. An important unanswered question is whether the loss of cardiac β-adrenergic receptor responsiveness is a contributing cause, or a result, of ventricular dysfunction. Even though this question remains unanswered, the concept of targeting the β-adrenergic pathway in the failing heart is becoming increasingly popular and several new therapeutic strategies are in development. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | β-ADRENERGIC RECEPTORS AND RECEPTOR SIGNALING IN HEART FAILURE |
| DOI | 10.1146/annurev.pharmtox.39.1.343 |
| Print ISSN | 0362-1642 |
| Журнал | Annual Review of Pharmacology and Toxicology |
| Том | 39 |
| Первая страница | 343 |
| Последняя страница | 360 |
| Аффилиация | Post, Steven R.; Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, Kentucky 40536-0284 |
