| Автор | Sah, Valerie P. |
| Автор | Seasholtz, Tammy M. |
| Автор | Sagi, Sarah A. |
| Автор | Brown, Joan Heller |
| Дата выпуска | 2000 |
| dc.description | Low molecular weight G proteins of the Rho subfamily are regulators of actin cytoskeletal organization. In contrast to the heterotrimeric G proteins, the small GTPases are not directly activated through ligand binding to G protein–coupled receptors (GPCRs). However, a subset of GPCRs, including those for lysophosphatidic acid and thrombin, induce stress fibers, focal adhesions, and cell rounding through Rho-dependent pathways. C3 exoenzyme has been a useful tool for demonstrating Rho involvement in these and other responses, including Ca<sup>2+</sup> sensitization of smooth muscle contraction, cell migration, transformation, and serum response element–mediated gene expression. Most of the GPCRs that induce Rho-dependent responses can activate Gq, but this is not a sufficient signal. Recent data demonstrate that Gα12/13 can induce Rho-dependent responses. Furthermore, Gα12/13 can bind and activate Rho-specific guanine nucleotide exchange factors, providing a mechanism by which GPCRs that couple to Gα12/13 could activate Rho and its downstream responses. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | The Role of Rho in G Protein-Coupled Receptor Signal Transduction |
| DOI | 10.1146/annurev.pharmtox.40.1.459 |
| Print ISSN | 0362-1642 |
| Журнал | Annual Review of Pharmacology and Toxicology |
| Том | 40 |
| Первая страница | 459 |
| Последняя страница | 489 |
| Аффилиация | Sah, Valerie P.; Department of Pharmacology, University of California, San Diego, California, 92093– 0636; email: vtansah@ucsd.edu , tseasholtz@ucsd.edu , ssagi@ucsd.edu , and jhbrown@ucsd.edu |
