| Автор | Fu, Haian |
| Автор | Subramanian, Romesh R. |
| Автор | Masters, Shane C. |
| Дата выпуска | 2000 |
| dc.description | The 14-3-3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells. A striking feature of the 14-3-3 proteins is their ability to bind a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. This plethora of interacting proteins allows 14-3-3 to play important roles in a wide range of vital regulatory processes, such as mitogenic signal transduction, apoptotic cell death, and cell cycle control. In this review, we examine the structural basis for 14-3-3–ligand interactions, proposed functions of 14-3-3 in various signaling pathways, and emerging views of mechanisms that regulate 14-3-3 actions. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | 14-3-3 Proteins: Structure, Function, and Regulation |
| DOI | 10.1146/annurev.pharmtox.40.1.617 |
| Print ISSN | 0362-1642 |
| Журнал | Annual Review of Pharmacology and Toxicology |
| Том | 40 |
| Первая страница | 617 |
| Последняя страница | 647 |
| Аффилиация | Fu, Haian; Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322; email: hfu@pharm.emory.edu , rsubram@emory.edu , smast01@emory.edu |
