Modelling of cardiac-related changes in lung resistivity measured with EITS
Tian-Xian Zhao; Brian H Brown; Peter Nopp; Wei Wang; Andrew D Leathard; Li-Qin Lu; Tian-Xian Zhao; Department of Medical Physics and Clinical Engineering, The University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK; Brian H Brown; Department of Medical Physics and Clinical Engineering, The University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK; Peter Nopp; Department of Medical Physics and Clinical Engineering, The University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK; Wei Wang; Department of Medical Physics and Clinical Engineering, The University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK; Andrew D Leathard; Department of Medical Physics and Clinical Engineering, The University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK; Li-Qin Lu; Department of Medical Physics and Clinical Engineering, The University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
Журнал:
Physiological Measurement
Дата:
1996-11-01
Аннотация:
Resistivity data from 9.6 kHz to 1.2 MHz were recorded from eight normal subjects using an electrical impedance tomographic spectroscopy (EITS) system and then averaged to a mean cardiac cycle using the ECG gating technique. The Cole - Cole model, that is, extracellular resistance R connected in parallel with intracellular resistance S and membrane capacitance C in series, with a distribution parameter a, was applied to model the frequency characteristics and to produce parametric images. During systole, SC and RC were found to decrease and FR increase. The changes in R/S were not consistent among the subjects. We estimated the peak changes in R, S and C to be -2.5%, -3.3% and -7.6% respectively. The results can be explained by considering the blood vessels as spheres of different sizes with blood inside them. The decrease in R during systole might be caused by the increased blood content in relatively large vessels, whereas that in S by the increased blood volume in relatively small vessels. The capacitance of blood is normally smaller than that of lung tissue, whereas FR of blood is higher than that of lung tissue. Hence, as blood content increases, C should decrease and FR increase.
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