| Автор | Boekelheide, Kim |
| Автор | Fleming, Shawna L. |
| Автор | Allio, Theresa |
| Автор | Embree-Ku, Michelle E. |
| Автор | Hall, Susan J. |
| Автор | Johnson, Kamin J. |
| Автор | Kwon, Eun Ji |
| Автор | Patel, Sutchin R. |
| Автор | Rasoulpour, Reza J. |
| Автор | Schoenfeld, Heidi A. |
| Автор | Thompson, Stephanie |
| Дата выпуска | 2003 |
| dc.description | ▪ Abstract Now in its third decade of mechanistic investigation, testicular injury caused by 2,5-hexanedione (2,5-HD) exposure is a well-studied model with a rich database. The development of this model reflects the larger changes that have moved biology from a branch of chemistry into the molecular age. Critically examined in this review is the proposed mechanism for 2,5-HD-induced testicular injury in which germ cell maturation is disrupted owing to alterations in Sertoli cell microtubule-mediated functions. The goal is to evaluate the technical and conceptual approaches used to assess 2,5-HD-induced testicular injury, to highlight unanswered questions, and to identify fruitful avenues of future research. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | 2,5-HEXANEDIONE-INDUCED TESTICULAR INJURY |
| DOI | 10.1146/annurev.pharmtox.43.100901.135930 |
| Print ISSN | 0362-1642 |
| Журнал | Annual Review of Pharmacology and Toxicology |
| Том | 43 |
| Первая страница | 125 |
| Последняя страница | 147 |
| Аффилиация | Boekelheide, Kim; Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912; email: Kim_Boekelheide@Brown.edu |
