| Автор | Clancy, Colleen E. |
| Автор | Kurokawa, Junko |
| Автор | Tateyama, Michihiro |
| Автор | Wehrens, Xander H.T. |
| Автор | Kass, Robert S. |
| Дата выпуска | 2003 |
| dc.description | ▪ Abstract Pharmacological intervention, often for the purpose of treating syndromes unrelated to cardiac disease, can increase the vulnerability of some patients to life-threatening rhythm disturbances. This may be due to an underlying propensity stemming from genetic defects or polymorphisms, or structural abnormalities that provide a substrate allowing for the initiation of arrhythmic triggers. A number of pharmacological agents that have proven useful in the treatment of allergic reactions, gastrointestinal disorders, and psychotic disorders, among others, have been shown to reduce repolarizing K<sup>+</sup> currents and prolong the QT interval on the electrocardiogram. Understanding the structural determinants of K<sup>+</sup> channel blockade may provide new insights into the mechanism and rate-dependent effects of drugs on cellular physiology. Drug-induced disruption of cellular repolarization underlies electrocardiographic abnormalities that are diagnostic indicators of arrhythmia susceptibility. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | K<sup>+</sup> CHANNEL STRUCTURE-ACTIVITY RELATIONSHIPS AND MECHANISMS OF DRUG-INDUCED QT PROLONGATION |
| DOI | 10.1146/annurev.pharmtox.43.100901.140245 |
| Print ISSN | 0362-1642 |
| Журнал | Annual Review of Pharmacology and Toxicology |
| Том | 43 |
| Первая страница | 441 |
| Последняя страница | 461 |
| Аффилиация | Clancy, Colleen E.; Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032; e-mail: cc2114@columbia.edu jk878@columbia.edu mt768@columbia.edu xw80@columbia.edu rsk20@columbia.edu |
