| Автор | Lafontan, Max |
| Дата выпуска | 2005 |
| dc.description | ▪ Abstract For a long time neural and endocrine messages were studied for their impact on adipocyte metabolism and control of storage/release of fatty acids. In fact, bidirectional communication exists between adipocytes and other tissues. Several molecules secreted from adipocytes are involved in fat cell signaling to other tissues. Adipocyte products could initiate antagonistic effects on target tissues. Fat cells produce peptides that can elicit insulin resistance, such as tumor necrosis factor-α and resistin, as well as hormones that can improve insulin resistance, such as leptin and adiponectin. Secretion of complement proteins, proinflammatory cytokines, procoagulant, and acute phase reactant proteins have also been observed in adipocytes. There is much to learn about how these signals function. It is unlikely that all the adipocyte's endocrine and paracrine signals have been identified. Putative pharmacological strategies aiming at modulation of afferent and efferent fat cell messages are reviewed and discussed. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | FAT CELLS: Afferent and Efferent Messages Define New Approaches to Treat Obesity |
| DOI | 10.1146/annurev.pharmtox.45.120403.095843 |
| Print ISSN | 0362-1642 |
| Журнал | Annual Review of Pharmacology and Toxicology |
| Том | 45 |
| Первая страница | 119 |
| Последняя страница | 146 |
| Аффилиация | Lafontan, Max; Obesity Research Unit, French Institute of Health and Medical Research (Inserm-UPS-Unit 586), Université Paul Sabatier, Institut Louis Bugnard, Hôpital Rangueil, TSA50032, 31059 Toulouse cedex 9, France; email: max.lafontan@toulouse.inserm.fr |
