| Автор | Michael Blomquist |
| Автор | Jinsheng Li |
| Автор | Chang-Ming Ma |
| Автор | Björn Zackrisson |
| Автор | Mikael Karlsson |
| Дата выпуска | 2002-03-21 |
| dc.description | Radiation therapy in the thoracic region is difficult due to the presence of many dose-limiting structures and the large density differences that affect the dose distribution. Conventional irradiation techniques use low-energy photon beams to avoid build-up effects superficially in the tumour and increased lateral scattering of the beams. For deep-seated tumours higher beam energies could have lung-sparing properties that would enable dose escalation.A comparison was made for a conventional low photon energy (6 MV) and 50 MV photons for the treatment of a lung tumour. A representative patient geometry was selected, consisting of a small tumour semi-enclosed in lung tissue. Treatment plans were designed using a commercial 3D-pencil beam treatment planning system. The treatment beams designed in the TPS were simulated with the Monte Carlo code EGS4/BEAM and the dose distribution in the phantom created from the patients CT-data was calculated using MCDOSE with identical beam geometry for both energies.The intrinsic difference between the two photon energies implies a sparing effect of lung that can be utilized for dose escalation. For a treatment with two beams the mean total dose to the tumour could be increased by 5.3 for 50 MV, corresponding to 3.2 Gy for a prescription dose of 60 Gy, with the same complication probability for the treated lung as for 6 MV.In conclusion, high-energy beams have qualities that can be taken advantage of for irradiation of lung tumours. Optimum solutions would probably require the use of both high- and low-energy beams. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Название | Comparison between a conventional treatment energy and 50 MV photons for the treatment of lung tumours |
| Тип | paper |
| DOI | 10.1088/0031-9155/47/6/303 |
| Electronic ISSN | 1361-6560 |
| Print ISSN | 0031-9155 |
| Журнал | Physics in Medicine and Biology |
| Том | 47 |
| Первая страница | 889 |
| Последняя страница | 897 |
| Выпуск | 6 |
