| Автор | Wiwat Youngdee |
| Автор | David J Lurie |
| Автор | Margaret A Foster |
| Дата выпуска | 2002-04-07 |
| dc.description | A new pulse sequence for rapid imaging of free radicals is presented which combines snapshot imaging methods and conventional field-cycled proton electron double resonance imaging (FC-PEDRI). The new sequence allows the number of EPR irradiation periods to be optimized to obtain an acceptable SNR and spatial resolution of free radical distribution in the final image while reducing the RF power deposition and increasing the temporal resolution. Centric reordered phase encoding has been employed to counter the problem of rapid decay of the Overhauser-enhanced signal. A phase-correction scheme has also been used to correct problems arising from instability of the magnetic field following field-cycling. In vivo experiments were carried out using triaryl methyl free radical contrast agent, injected at a dose of 0.214 mmol kg<sup>−1</sup> body weight in anaesthetized adult male Sprague–Dawley rats. Transaxial images through the abdomen were collected using 1, 2, 4 and 8 EPR irradiation periods. Using 4 EPR irradiation periods it was possible to generate free radical distributions of acceptable SNR and resolution. The EPR power deposition is reduced by a factor of 16 and the acquisition time is reduced by a factor of 4 compared to an acquisition using the conventional FC-PEDRI pulse sequence. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Название | Rapid imaging of free radicals in vivo using hybrid FISP field-cycled PEDRI |
| Тип | paper |
| DOI | 10.1088/0031-9155/47/7/307 |
| Electronic ISSN | 1361-6560 |
| Print ISSN | 0031-9155 |
| Журнал | Physics in Medicine and Biology |
| Том | 47 |
| Первая страница | 1091 |
| Последняя страница | 1100 |
| Аффилиация | Wiwat Youngdee; Department of Bio-Medical Physics and Bio-Engineering, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK |
| Аффилиация | David J Lurie; Department of Bio-Medical Physics and Bio-Engineering, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK |
| Аффилиация | Margaret A Foster; Department of Bio-Medical Physics and Bio-Engineering, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK |
| Выпуск | 7 |
