| Автор | Feder, Martin E. |
| Автор | Hofmann, Gretchen E. |
| Дата выпуска | 1999 |
| dc.description | ▪ Abstract Molecular chaperones, including the heat-shock proteins (Hsps), are a ubiquitous feature of cells in which these proteins cope with stress-induced denaturation of other proteins. Hsps have received the most attention in model organisms undergoing experimental stress in the laboratory, and the function of Hsps at the molecular and cellular level is becoming well understood in this context. A complementary focus is now emerging on the Hsps of both model and nonmodel organisms undergoing stress in nature, on the roles of Hsps in the stress physiology of whole multicellular eukaryotes and the tissues and organs they comprise, and on the ecological and evolutionary correlates of variation in Hsps and the genes that encode them. This focus discloses that (a) expression of Hsps can occur in nature, (b) all species have hsp genes but they vary in the patterns of their expression, (c) Hsp expression can be correlated with resistance to stress, and (d) species' thresholds for Hsp expression are correlated with levels of stress that they naturally undergo. These conclusions are now well established and may require little additional confirmation; many significant questions remain unanswered concerning both the mechanisms of Hsp-mediated stress tolerance at the organismal level and the evolutionary mechanisms that have diversified the hsp genes. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | HEAT-SHOCK PROTEINS, MOLECULAR CHAPERONES, AND THE STRESS RESPONSE: Evolutionary and Ecological Physiology |
| DOI | 10.1146/annurev.physiol.61.1.243 |
| Print ISSN | 0066-4278 |
| Журнал | Annual Review of Physiology |
| Том | 61 |
| Первая страница | 243 |
| Последняя страница | 282 |
| Аффилиация | Feder, Martin E.; Department of Organismal Biology and Anatomy and Committee on Evolutionary Biology, University of Chicago, 1027 East 57th Street, Chicago, Illinois 60637; e-mail: m-feder@uchicago.edu |
