| Автор | Baumgartner, I |
| Автор | Isner, JM |
| Дата выпуска | 2001 |
| dc.description | ▪ Abstract This review surveys a range of approaches using plasmid DNA encoding the 165-amino-acid isoform of vascular endothelial growth factor (phVEGF165) to therapeutically modulate micro- or macrovascular endothelial cells, focusing on strategies to augment postnatal collateral circulation in arterial insufficiency or to accelerate re-endothelialization after balloon angioplasty to prevent restenosis. We focus on intra-arterial and intramuscular/intramyocardial gene transfer of the VEGF165 gene, the options that have been most thoroughly studied to date in patients. We review developmental and postnatal significance of the endothelial-cell-specific mitogen VEGF that has stimulated these studies and present limitations of current knowledge as well as challenges for the future. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | SOMATIC GENE THERAPY IN THE CARDIOVASCULAR SYSTEM |
| DOI | 10.1146/annurev.physiol.63.1.427 |
| Print ISSN | 0066-4278 |
| Журнал | Annual Review of Physiology |
| Том | 63 |
| Первая страница | 427 |
| Последняя страница | 450 |
| Аффилиация | Baumgartner, I; Swiss Cardiovascular Center, Division Angiology, University Hospital, Bern, 3010 Switzerland; e-mail: iris.baumgartner@insel.ch |
