| Автор | Murer, Heini |
| Автор | Hernando, Nati |
| Автор | Forster, Ian |
| Автор | Biber, Jürg |
| Дата выпуска | 2003 |
| dc.description | ▪ Abstract The physiological tuning and pathophysiological alterations of renal proximal reabsorption of inorganic phosphate can be ascribed to the net amount of the Na/Pi-cotransporter NaPi-IIa localized in the brush border membrane. The net amount of NaPi-IIa appears to be the result of an endocytotic rate regulated by a complex network of different protein kinases. New approaches demonstrated that NaPi-IIa is part of heteromeric protein complexes, organized by PDZ (postsynaptic protein PSD95, Drosophila junction protein Disc-large, tight junction protein ZO-1) proteins. Such complexes are thought to play important roles in the apical positioning and regulated endocytosis of NaPi-IIa and therefore such interactions have to be considered when explaining proximal phosphate ion reabsorption. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | REGULATION OF Na/Pi TRANSPORTER IN THE PROXIMAL TUBULE |
| DOI | 10.1146/annurev.physiol.65.042902.092424 |
| Print ISSN | 0066-4278 |
| Журнал | Annual Review of Physiology |
| Том | 65 |
| Первая страница | 531 |
| Последняя страница | 542 |
| Аффилиация | Murer, Heini; Institute of Physiology, University Zürich, 8057 Switzerland; e-mail: hmurer@access.unizh.ch hernando@physiol.unizh.ch iforster@access.unizh.ch JuergBiber@access.unizh.ch |
