| Автор | Kobayashi, Tomoyoshi |
| Автор | Solaro, R. John |
| Дата выпуска | 2005 |
| dc.description | ▪ Abstract Although well known as the location of the mechanism by which the cardiac sarcomere is activated by Ca<sup>2+</sup> to generate force and shortening, the thin filament is now also recognized as a vital component determining the dynamics of contraction and relaxation. Molecular signaling in the thin filament involves steric, allosteric, and cooperative mechanisms that are modified by protein phosphorylation, sarcomere length and load, the chemical environment, and isoform composition. Approaches employing transgenesis and mutagenesis now permit investigation of these processes at the level of the systems biology of the heart. These studies reveal that the thin filaments are not merely slaves to the levels of Ca<sup>2+</sup> determined by membrane channels, transporters and exchangers, but are actively involved in beat to beat control of cardiac function by neural and hormonal factors and by the Frank-Starling mechanism. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | CALCIUM, THIN FILAMENTS, AND THE INTEGRATIVE BIOLOGY OF CARDIAC CONTRACTILITY |
| DOI | 10.1146/annurev.physiol.67.040403.114025 |
| Print ISSN | 0066-4278 |
| Журнал | Annual Review of Physiology |
| Том | 67 |
| Первая страница | 39 |
| Последняя страница | 67 |
| Аффилиация | Kobayashi, Tomoyoshi; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612; email: solarorj@uic.edu ; tkoba@uic.edu |
