| Автор | Dreher, Theo W. |
| Дата выпуска | 1999 |
| dc.description | ▪ Abstract Positive strand RNA viral genomes are unique in the viral world in serving a dual role as mRNA and replicon. Since the origin of the minus-strand RNA replication intermediate is at the 3′-end of the genome, the 3′-untranslated region (UTR) clearly plays a role in viral RNA replication. The messenger role of this same RNA likely places functional demands on the 3′-UTR to serve roles typical of cellular mRNAs, including the regulation of RNA stability and translation. Current understanding indicates varied roles for positive strand RNA viral 3′-UTRs, with the dominant roles differing between viruses. Three case studies are discussed: turnip yellow mosaic virus RNA, whose 3′ tRNA mimicry is thought to negatively regulate minus strand synthesis; brome mosaic virus, whose 3′-UTR contains a unique promoter element directing minus strand synthesis; and tobacco mosaic virus, whose 3′-UTR contains an enhancer of translational expression. |
| Формат | application.pdf |
| Издатель | Annual Reviews |
| Копирайт | Annual Reviews |
| Название | FUNCTIONS OF THE 3′-UNTRANSLATED REGIONS OF POSITIVE STRAND RNA VIRAL GENOMES |
| DOI | 10.1146/annurev.phyto.37.1.151 |
| Print ISSN | 0066-4286 |
| Журнал | Annual Review of Phytopathology |
| Том | 37 |
| Первая страница | 151 |
| Последняя страница | 174 |
| Аффилиация | Dreher, Theo W.; Department of Microbiology and Center for Gene Research and Biotechnology, Oregon State University, Corvallis, Oregon 97331-3804; e-mail: drehert@bcc.orst.edu |
