| Автор | Yadav, Jhillu S |
| Автор | Lavanya, Madugula P |
| Автор | Das, Pragna P |
| Автор | Bag, Indira |
| Автор | Krishnan, Anita |
| Автор | Jagannadh, Bulusu |
| Автор | Mohapatra, Debendra K |
| Автор | Bhadra, Manika Pal |
| Автор | Bhadra, Utpal |
| Дата выпуска | 2010-04-16 |
| dc.description | p-aminobenzoic acid (PABA), a structural moiety of many commercial drugs, is self-assembled with linker alkyl side chains to form tubular nanostructures. The tubes exhibited fluorescence either intrinsic or from fluorescent molecules embedded in the wall during self-assembly. Uptake and inter-cellular delivery of the conjugated nanotubes in human cancer cells and in mouse embryonic stem cells were demonstrated by fluorescence imaging and flow cytometry. Biocompatibility, cytotoxicity and clearance were monitored both ex vivo in mouse multipotent embryonic stem cells and in vivo in adult Drosophila. Accumulation of nanotubes had no adverse effects and abnormalities on stem cell morphology and proliferation rate. A distinct distribution of two separate nanotubes in various internal organs of Drosophila interprets that accumulation of nanomaterials might be interdependent on the side chain modifications and physiological settings of cell or tissue types. Unlike carbon nanomaterials, exposure of PABA nanotubes does not produce any hazards including locomotion defects and mortality of adult flies. Despite differential uptake and clearance from multiple live tissues, the use of self-assembled nanotubes can add new dimensions and scope to the development of dual-purpose oral carriers for the fulfilment of many biological promises. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | IOP Publishing Ltd |
| Название | 4-N-pyridin-2-yl-benzamide nanotubes compatible with mouse stem cell and oral delivery in Drosophila |
| Тип | paper |
| DOI | 10.1088/0957-4484/21/15/155102 |
| Electronic ISSN | 1361-6528 |
| Print ISSN | 0957-4484 |
| Журнал | Nanotechnology |
| Том | 21 |
| Первая страница | 155102 |
| Последняя страница | 155110 |
| Аффилиация | Yadav, Jhillu S; Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India |
| Аффилиация | Lavanya, Madugula P; Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India |
| Аффилиация | Das, Pragna P; Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India |
| Аффилиация | Bag, Indira; Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India |
| Аффилиация | Krishnan, Anita; Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India |
| Аффилиация | Jagannadh, Bulusu; Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India |
| Аффилиация | Mohapatra, Debendra K; Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India |
| Аффилиация | Bhadra, Manika Pal; Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500007, India |
| Аффилиация | Bhadra, Utpal; Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India |
| Выпуск | 15 |
