| Автор | Tabassum, Sartaj |
| Автор | Chandra Sharma, Girish |
| Автор | Arjmand, Farukh |
| Автор | Azam, Ameer |
| Дата выпуска | 2010-05-14 |
| dc.description | A new nano dimensional heterobimetallic Cu–Sn containing complex as a potential drug candidate was designed, synthesized and characterized by analytical and spectral methods. The electronic absorption and electron paramagnetic resonance parameters of the complex revealed that the Cu(II) ion exhibits a square pyramidal geometry with the two pyrazole nitrogen atoms, the amine nitrogen atom and the carboxylate oxygen of the phenyl glycine chloride ligand located at the equatorial sites and the coordinated chloride ion occupying an apical position. <sup>119</sup>Sn NMR spectral data showed a hexa-coordinated environment around the Sn(IV) metal ion. TEM, AFM and XRD measurements illustrate that the complex could induce the condensation of CT-DNA to a particulate nanostructure. The interaction of the Cu–Sn complex with CT-DNA was investigated by UV–vis absorption and emission spectroscopy, as well as cyclic voltammetric measurements. The results indicated that the complex interacts with DNA through an electrostatic mode of binding with an intrinsic binding constant K<sub>b</sub> = 8.42 × 10<sup>4</sup> M<sup> − 1</sup>. The Cu–Sn complex exhibits effective cleavage of pBR322 plasmid DNA by an oxidative cleavage mechanism, monitored at different concentrations both in the absence and in the presence of reducing agents. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | IOP Publishing Ltd |
| Название | DNA interaction studies of new nano metal based anticancer agent: validation by spectroscopic methods |
| Тип | paper |
| DOI | 10.1088/0957-4484/21/19/195102 |
| Electronic ISSN | 1361-6528 |
| Print ISSN | 0957-4484 |
| Журнал | Nanotechnology |
| Том | 21 |
| Первая страница | 195102 |
| Последняя страница | 195111 |
| Аффилиация | Tabassum, Sartaj; Department of Chemistry, Aligarh Muslim University, Aligarh-202002, India ; |
| Аффилиация | Chandra Sharma, Girish; Department of Chemistry, Aligarh Muslim University, Aligarh-202002, India |
| Аффилиация | Arjmand, Farukh; Department of Chemistry, Aligarh Muslim University, Aligarh-202002, India |
| Аффилиация | Azam, Ameer; Center of Excellence in Materials Science (Nanomaterials), Department of Applied Physics, Aligarh Muslim University, Aligarh 202002, UP, India |
| Выпуск | 19 |
