| Автор | Legrand, Bernard |
| Автор | Ashcroft, Alison E |
| Автор | Buchaillot, Lionel |
| Автор | Arscott, Steve |
| Дата выпуска | 2007-03-01 |
| dc.description | We present here micromachined nanoelectrospray emitter tips based on a microfluidic capillary slot fabricated using silicon-on-insulator (SOI) technology. We couple microelectromechanical systems (MEMS) and microfluidic design rules to ensure the rigidity of the structures by taking into account the effect of capillary forces generated by the introduction of liquids into MEMS. The SOI-based microtechnology fabrication process uses four simple steps: photolithography, dry etching, wet etching and dicing. This optimized fabrication process enables cost-effective batch production of chip-based micromachined nanoelectrospray emitter tips. The characteristics of these nanoelectrospray emitter tips were investigated using mass spectrometry. We have detected the protein lysozyme at a concentration as low as 100 fmol µL<sup>−1</sup>; our results indicate that micromachined electrospray emitter tips are useful in biomolecular analysis. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | 2007 IOP Publishing Ltd |
| Название | SOI-based nanoelectrospray emitter tips for mass spectrometry: a coupled MEMS and microfluidic design |
| Тип | paper |
| DOI | 10.1088/0960-1317/17/3/013 |
| Electronic ISSN | 1361-6439 |
| Print ISSN | 0960-1317 |
| Журнал | Journal of Micromechanics and Microengineering |
| Том | 17 |
| Первая страница | 509 |
| Последняя страница | 514 |
| Последняя страница | 514 |
| Аффилиация | Legrand, Bernard; Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN), CNRS UMR8520, ISEN Dept., Avenue Poincaré, Cité Scientifique, Villeneuve d'Ascq 59652, France |
| Аффилиация | Ashcroft, Alison E; Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK |
| Аффилиация | Buchaillot, Lionel; Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN), CNRS UMR8520, ISEN Dept., Avenue Poincaré, Cité Scientifique, Villeneuve d'Ascq 59652, France |
| Аффилиация | Arscott, Steve; Institut d'Electronique, de Microélectronique et de Nanotechnologie (IEMN), CNRS UMR8520, ISEN Dept., Avenue Poincaré, Cité Scientifique, Villeneuve d'Ascq 59652, France |
| Выпуск | 3 |
