| Автор | Graham A Wright |
| Автор | Mark McDade |
| Автор | William Keeble |
| Автор | William Martin |
| Автор | Ian Hutton |
| Дата выпуска | 2001-05-01 |
| dc.description | Gated SPECT (GSPECT) was evaluated for the measurement of left ventricular ejection fraction (LVEF) by comparing with equilibrium gated radionuclide ventriculography (RNVG). A total of 99 subjects underwent GSPECT and RNVG imaging. All studies were acquired in list mode with GSPECT studies processed to give 16- and 8-frames per R-R interval, and RNVG studies 24 frames per R-R interval. The Cedars-Sinai QGS software was used to calculate ejection fraction from GSPECT studies. RNVG studies were processed using a manually drawn single region of interest technique. Comparison of LVEF from GSPECT with RNVG yielded correlation coefficients of 0.82 and 0.81 for 16- and 8-frame GSPECT studies respectively. The mean 95% prediction interval was 33±11 percentage points for both 16- and 8-frame studies, indicating a great disparity between predicted ejection fraction values from GSPECT and actual RNVG values. Subgroup analysis of 29 patients with pathological Q-wave evidence of myocardial infarction demonstrated a poorer correlation coefficient of r = 0.69. Subgroup analysis of 32 patients with end-diastolic volumes <100 ml demonstrated a poorer correlation coefficient of r = 0.32. Ejection fractions calculated from 16- and 8-frame studies showed a correlation of 0.99 with a mean 95% prediction interval of 8.7±0.04 percentage points. The 8-frame studies underestimated LVEF by 3.6±2.3% compared to the 16-frame studies. In conclusion, left ventricular ejection fractions calculated using the QGS algorithm from GSPECT studies are inadequate for use in clinical practice. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Название | Are ejection fractions from gated SPECT perfusion studies clinically useful? A comparison with radionuclide ventriculography |
| Тип | paper |
| DOI | 10.1088/0967-3334/22/2/312 |
| Electronic ISSN | 1361-6579 |
| Print ISSN | 0967-3334 |
| Журнал | Physiological Measurement |
| Том | 22 |
| Первая страница | 413 |
| Последняя страница | 422 |
| Выпуск | 2 |
