We discuss the physics case of a high luminosity B-Factory running at the Υ(5S) resonance. We show that the coherence of the B meson pairs is preserved at this resonance, and that B_s can be well distinguished from B_d and charged B mesons. These facts allow to cover the physics program of a traditional B-Factory and, at the same time, to perform complementary measurements which are not accessible at the Υ(4S). In particular we show how, despite the experimental limitations in performing time-dependent measurements of B_s decays, the same experimental information can be extracted, in several cases, from the determination of time-integrated observables. In addition, a few examples of the potentiality in measuring rare B_s decays are given. Finally, we discuss how the study of B_s meson will improve the constraints on New Physics parameters in the B_s sector, in the context of the generalized Unitarity Triangle analysis.