| Автор | Joung, Yoon Ki |
| Автор | Sengoku, Yoichi |
| Автор | Ooya, Tooru |
| Автор | Park, Ki Dong |
| Автор | Yui, Nobuhiko |
| Дата выпуска | 2005-07-31 |
| dc.description | Polyrotaxanes with both sulfonyl and carboxyl groups were synthesized and characterized for mimicking the anticoagulant activity of heparin. A polyrotaxane consisting of α-cyclodextrins (α-CDs) and poly(ethylene glycol) (PEG) was synthesized, and carboxyethylester (CEE) groups and taurine were successively conjugated with the polyrotaxane to obtain taurine-conjugated carboxyethylester-polyrotaxanes (TAU-CEE-PRxs). The number of α-CDs and the anionic groups could be varied by synthetic conditions. The structural factors of TAU-CEE-PRxs affecting anticoagulant activity were suggested as following: (i) relatively lower threading percentage of α-CDs, (ii) the ratio of anionic groups similar to heparin, and (iii) lower molecular weight of PEG. The TAU-CEE-PRx that sufficiently meet the mentioned requirements showed enhanced antithrombin III (AT III) activity, indicating that the TAU-CEE-PRx interacts with AT III and/or thrombin. From these results, it is suggested that the sliding and rotation of free α-CDs with anionic groups are related with enhancing anticoagulant activity. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | © 2005 Elsevier Ltd |
| Название | Anticoagulant supramolecular-structured polymers: Synthesis and anticoagulant activity of taurine-conjugated carboxyethylester-polyrotaxanes |
| Тип | paper |
| DOI | 10.1016/j.stam.2005.03.013 |
| Electronic ISSN | 1878-5514 |
| Print ISSN | 1468-6996 |
| Журнал | Science and Technology of Advanced Materials |
| Том | 6 |
| Первая страница | 484 |
| Последняя страница | 490 |
| Аффилиация | Joung, Yoon Ki; School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Tatsunokuchi, Ishikawa 923-1292, Japan |
| Аффилиация | Sengoku, Yoichi; School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Tatsunokuchi, Ishikawa 923-1292, Japan |
| Аффилиация | Ooya, Tooru; School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Tatsunokuchi, Ishikawa 923-1292, Japan |
| Аффилиация | Park, Ki Dong; Department of Molecular Science and Technology, Ajou University, 5 Wonchon, Youngtong, Suwon 442-749, South Korea |
| Аффилиация | Yui, Nobuhiko; School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Tatsunokuchi, Ishikawa 923-1292, Japan; |
| Выпуск | 5 |
