| Автор | Bernauer, Julie |
| Автор | Poupon, Anne |
| Автор | Azé, Jérôme |
| Автор | Janin, Joël |
| Дата выпуска | 2005-06-01 |
| dc.description | We describe protein–protein recognition within the frame of the random energy model of statistical physics. We simulate, by docking the component proteins, the process of association of two proteins that form a complex. We obtain the energy spectrum of a set of protein–protein complexes of known three-dimensional structure by performing docking in random orientations and scoring the models thus generated. We use a coarse protein representation where each amino acid residue is replaced by its Voronoï cell, and derive a scoring function by applying the evolutionary learning program ROGER to a set of parameters measured on that representation. Taking the scores of the docking models to be interaction energies, we obtain energy spectra for the complexes and fit them to a Gaussian distribution, from which we derive physical parameters such as a glass transition temperature and a specificity transition temperature. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | 2005 IOP Publishing Ltd |
| Название | A docking analysis of the statistical physics of protein–protein recognition |
| Тип | paper |
| DOI | 10.1088/1478-3975/2/2/S02 |
| Electronic ISSN | 1478-3975 |
| Print ISSN | 1478-3967 |
| Журнал | Physical Biology |
| Том | 2 |
| Первая страница | S17 |
| Последняя страница | S23 |
| Аффилиация | Bernauer, Julie; Yeast Structural Genomics Laboratory, IBBMC UMR CNRS 8619, Bâtiment 430, Université Paris-Sud, 91405-Orsay, France |
| Аффилиация | Poupon, Anne; Yeast Structural Genomics Laboratory, IBBMC UMR CNRS 8619, Bâtiment 430, Université Paris-Sud, 91405-Orsay, France |
| Аффилиация | Azé, Jérôme; Laboratoire de Recherche en Informatique, Bâtiment 490, Université Paris-Sud, 91405-Orsay, France |
| Аффилиация | Janin, Joël; Laboratoire d'Enzymologie et Biochimie Structurales, UPR 9063 CNRS, 91198-Gif-sur-Yvette, France |
| Выпуск | 2 |
