| Автор | Aubert, M |
| Автор | Badoual, M |
| Автор | Féreol, S |
| Автор | Christov, C |
| Автор | Grammaticos, B |
| Дата выпуска | 2006-06-01 |
| dc.description | We present a study of in vitro cell migration in two dimensions as a first step towards understanding the mechanisms governing the motility of glioma cells. Our study is based on a cellular automaton model which aims at reproducing the kinetics of a lump of glioma cells deposited on a substrate of collagen. The dynamical effects of cell attraction and motion inertia are introduced through adequate automaton rules. We compare the density profiles given by the model to those obtained experimentally. The result of the best fit indicates a substantial cell–cell attraction due to cell–cell communication through gap junctions (or chemotaxis) and negligible inertia effects during migration. Tracking of individual migrating cells indicates highly convoluted cell trajectories. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | 2006 IOP Publishing Ltd |
| Название | A cellular automaton model for the migration of glioma cells |
| Тип | paper |
| DOI | 10.1088/1478-3975/3/2/001 |
| Electronic ISSN | 1478-3975 |
| Print ISSN | 1478-3967 |
| Журнал | Physical Biology |
| Том | 3 |
| Первая страница | 93 |
| Последняя страница | 100 |
| Аффилиация | Aubert, M; GMPIB, Université Paris VII, case 7021, 75251 Paris, France |
| Аффилиация | Badoual, M; GMPIB, Université Paris VII, case 7021, 75251 Paris, France |
| Аффилиация | Féreol, S; Unité INSERM 492 (IM3), 94010 Créteil, France |
| Аффилиация | Christov, C; Plateforme d'Imagerie Cellulaire et Tissulaire de l'IFR10, Institut Mondor de Médecine Moléculaire, Paris, France |
| Аффилиация | Grammaticos, B; GMPIB, Université Paris VII, case 7021, 75251 Paris, France |
| Выпуск | 2 |
