| Автор | Bongini, Lorenzo |
| Автор | Fanelli, Duccio |
| Автор | Piazza, Francesco |
| Автор | De Los Rios, Paolo |
| Автор | Sanner, Michel |
| Автор | Skoglund, Ulf |
| Дата выпуска | 2007-09-01 |
| dc.description | The effects of internal dynamics in diffusion-driven encounters between macro-molecules represent a problem of broad relevance in molecular biology. In this view, we investigate a typical antigen–antibody reaction chain, based on a coarse-grained mechanical model parameterized directly upon results from single-molecule experiments. We demonstrate that the internal dynamics is a crucial factor in the encounter process. To describe our numerical results, we formulate a simple, intuitive theoretical framework, and we develop it analytically. This enables us to show that the inner dynamics of antibody molecules results in a cooperative behavior of their individual sub-units. Along the same lines, we also investigate the case of double binding to multi-valent antigens. Our results quantify the enhancement of avidity afforded by the double binding in excellent agreement with the available experimental data. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | 2007 IOP Publishing Ltd |
| Название | A dynamical study of antibody–antigen encounter reactions |
| Тип | paper |
| DOI | 10.1088/1478-3975/4/3/004 |
| Electronic ISSN | 1478-3975 |
| Print ISSN | 1478-3967 |
| Журнал | Physical Biology |
| Том | 4 |
| Первая страница | 172 |
| Последняя страница | 180 |
| Последняя страница | 180 |
| Аффилиация | Bongini, Lorenzo; Dipartimento di Fisica, Università di Firenze, V. G. Sansone 1, 50019 Firenze, Italy; These authors contributed equally to the work. |
| Аффилиация | Fanelli, Duccio; Theoretical Physics Group, School of Physics & Astronomy, University of Manchester, Manchester, UK; These authors contributed equally to the work. |
| Аффилиация | Piazza, Francesco; Institute of Theoretical Physics, EPFL SB ITP LBS, BSP 720, 1015 Lausanne, Switzerland; These authors contributed equally to the work. |
| Аффилиация | De Los Rios, Paolo; Institute of Theoretical Physics, EPFL SB ITP LBS, BSP 720, 1015 Lausanne, Switzerland |
| Аффилиация | Sanner, Michel; SCRIPPS, La Jolla CA 92037, USA |
| Аффилиация | Skoglund, Ulf; Cell and Molecular Biology Department, Karolinska Institutet, 171 71 Stockholm, Sweden |
| Выпуск | 3 |
