| Автор | Modchang, Charin |
| Автор | Nadkarni, Suhita |
| Автор | Bartol, Thomas M |
| Автор | Triampo, Wannapong |
| Автор | Sejnowski, Terrence J |
| Автор | Levine, Herbert |
| Автор | Rappel, Wouter-Jan |
| Дата выпуска | 2010-06-01 |
| dc.description | We study the calcium-induced vesicle release into the synaptic cleft using a deterministic algorithm and MCell, a Monte Carlo algorithm that tracks individual molecules. We compare the average vesicle release probability obtained using both algorithms and investigate the effect of the three main sources of noise: diffusion, sensor kinetics and fluctuations from the voltage-dependent calcium channels (VDCCs). We find that the stochastic opening kinetics of the VDCCs are the main contributors to differences in the release probability. Our results show that the deterministic calculations lead to reliable results, with an error of less than 20%, when the sensor is located at least 50 nm from the VDCCs, corresponding to microdomain signaling. For smaller distances, i.e. nanodomain signaling, the error becomes larger and a stochastic algorithm is necessary. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | 2010 IOP Publishing Ltd |
| Название | A comparison of deterministic and stochastic simulations of neuronal vesicle release models |
| Тип | paper |
| DOI | 10.1088/1478-3975/7/2/026008 |
| Electronic ISSN | 1478-3975 |
| Print ISSN | 1478-3967 |
| Журнал | Physical Biology |
| Том | 7 |
| Первая страница | 26008 |
| Последняя страница | 26014 |
| Аффилиация | Modchang, Charin; Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, CA 92093, USA; R&D Group of Biological and Environmental Physics, Department of Physics, Faculty of Science, Mahidol University, Bangkok 10400, Thailand |
| Аффилиация | Nadkarni, Suhita; Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, CA 92093, USA |
| Аффилиация | Bartol, Thomas M; Computational Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA |
| Аффилиация | Triampo, Wannapong; R&D Group of Biological and Environmental Physics, Department of Physics, Faculty of Science, Mahidol University, Bangkok 10400, Thailand |
| Аффилиация | Sejnowski, Terrence J; Howard Hughes Medical Institute and The Salk Institute for Biological Studies, La Jolla, CA 92037, USA |
| Аффилиация | Levine, Herbert; Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, CA 92093, USA |
| Аффилиация | Rappel, Wouter-Jan; Center for Theoretical Biological Physics, University of California, San Diego, La Jolla, CA 92093, USA |
| Выпуск | 2 |
