| Автор | Miriam E Gerlofs-Nijland |
| Автор | Arezoo Campbell |
| Автор | Mark R Miller |
| Автор | David E Newby |
| Автор | Flemming R Cassee |
| Дата выпуска | 2009-02-01 |
| dc.description | Traffic generated ultrafine particulates may play a major role in the development of adverse health effects. However, little is known about harmful effects caused by recurring exposure. We hypothesized that repeated exposure to particulate matter results in adverse pulmonary and systemic toxic effects. Exposure to diesel engine exhaust resulted in signs of oxidative stress in the lung, impaired coagulation, and changes in the immune system. Pro-inflammatory cytokine levels were decreased in some regions of the brain but increased in the striatum implying that exposure to diesel engine exhaust may selectively aggravate neurological impairment. Data from these three studies suggest that exposure to traffic related PM can mediate changes in the vasculature and brain of healthy rats. To what extent these changes may contribute to chronic neurodegenerative or vascular diseases is at present unclear. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | © 2009 IOP Publishing Ltd |
| Название | Toxicity of inhaled traffic related particulate matter |
| Тип | paper |
| DOI | 10.1088/1742-6596/151/1/012049 |
| Electronic ISSN | 1742-6596 |
| Print ISSN | 1742-6588 |
| Журнал | Journal of Physics: Conference Series |
| Том | 151 |
| Первая страница | 12049 |
| Последняя страница | 12053 |
| Выпуск | 1 |
