The Casimir densities are investigated for a massive spinor field in de Sitter space-time with an arbitrary number of toroidally compactified spatial dimensions. The vacuum expectation value of the energy-momentum tensor is presented in the form of the sum of corresponding quantity in the uncompactified de Sitter spacetime and the part induced by the non-trivial topology. The latter is finite and the renormalization is needed for the first part only. The asymptotic behavior of the topological term is investigated in the early and late stages of the cosmological expansion. When the comoving lengths of the compactified dimensions are much smaller than the de Sitter curvature radius, to the leading order the topological part coincides with the corresponding quantity for a massless fermionic field and is conformally related to the corresponding flat spacetime result with the same topology. In this limit the topo-logical term dominates the uncompactified de Sitter part and the back-reaction effects should be taken into account. In the opposite limit, for a massive field the asymptotic behavior of the topological part is damping oscillatory.