| Автор | Lima, Rui |
| Автор | Oliveira, Mónica S N |
| Автор | Ishikawa, Takuji |
| Автор | Kaji, Hirokazu |
| Автор | Tanaka, Shuji |
| Автор | Nishizawa, Matsuhiko |
| Автор | Yamaguchi, Takami |
| Дата выпуска | 2009-09-01 |
| dc.description | The current microdevices used for biomedical research are often manufactured using microelectromechanical systems (MEMS) technology. Although it is possible to fabricate precise and reproducible rectangular microchannels using soft lithography techniques, this kind of geometry may not reflect the actual physiology of the microcirculation. Here, we present a simple method to fabricate circular polydimethysiloxane (PDMS) microchannels aiming to mimic an in vivo microvascular environment and suitable for state-of-the-art microscale flow visualization techniques, such as confocal µPIV/PTV. By using a confocal µPTV system individual red blood cells (RBCs) were successfully tracked trough a 75 µm circular PDMS microchannel. The results show that RBC lateral dispersion increases with the volume fraction of RBCs in the solution, i.e. with the hematocrit. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | 2009 IOP Publishing Ltd |
| Название | Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies |
| Тип | paper |
| DOI | 10.1088/1758-5082/1/3/035005 |
| Electronic ISSN | 1758-5090 |
| Print ISSN | 1758-5082 |
| Журнал | Biofabrication |
| Том | 1 |
| Первая страница | 35005 |
| Последняя страница | 35011 |
| Аффилиация | Lima, Rui; Department of Mechanical Technology, ESTiG, Bragança Polyt., C. Sta. Apolonia, 5301-857 Bragança, Portugal; CEFT, Faculdade de Engenharia da Universidade do Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal; |
| Аффилиация | Oliveira, Mónica S N; Departamento de Engenharia Química, CEFT, Faculdade de Engenharia da Universidade do Porto, Rua Dr Roberto Frias, 4200-465 Porto, Portugal |
| Аффилиация | Ishikawa, Takuji; Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aoba, 980-8579 Sendai, Japan |
| Аффилиация | Kaji, Hirokazu; Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aoba, 980-8579 Sendai, Japan |
| Аффилиация | Tanaka, Shuji; Department of Nanomechanics, Graduate School of Engineering, Tohoku University, 6-6-01 Aoba, 980-8579 Sendai, Japan |
| Аффилиация | Nishizawa, Matsuhiko; Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aoba, 980-8579 Sendai, Japan |
| Аффилиация | Yamaguchi, Takami; Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6-01 Aoba, 980-8579 Sendai, Japan |
| Выпуск | 3 |
