| Автор | Cohen, Daniel L |
| Автор | Lipton, Jeffrey I |
| Автор | Bonassar, Lawrence J |
| Автор | Lipson, Hod |
| Дата выпуска | 2010-09-01 |
| dc.description | Tissue engineering holds great promise for injury repair and replacement of defective body parts. While a number of techniques exist for creating living biological constructs in vitro, none have been demonstrated for in situ repair. Using novel geometric feedback-based approaches and through development of appropriate printing-material combinations, we demonstrate the in situ repair of both chondral and osteochondral defects that mimic naturally occurring pathologies. A calf femur was mounted in a custom jig and held within a robocasting-based additive manufacturing (AM) system. Two defects were induced: one a cartilage-only representation of a grade IV chondral lesion and the other a two-material bone and cartilage fracture of the femoral condyle. Alginate hydrogel was used for the repair of cartilage; a novel formulation of demineralized bone matrix was used for bone repair. Repair prints for both defects had mean surface errors less than 0.1 mm. For the chondral defect, 42.8 ± 2.6% of the surface points had errors that were within a clinically acceptable error range; however, with 1 mm path planning shift, an estimated ∼75% of surface points could likely fall within the benchmark envelope. For the osteochondral defect, 83.6 ± 2.7% of surface points had errors that were within clinically acceptable limits. In addition to implications for minimally invasive AM-based clinical treatments, these proof-of-concept prints are some of the only in situ demonstrations to-date, wherein the substrate geometry was unknown a priori. The work presented herein demonstrates in situ AM, suggests potential biomedical applications and also explores in situ-specific issues, including geometric feedback, material selection and novel path planning techniques. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | 2010 IOP Publishing Ltd |
| Название | Additive manufacturing for in situ repair of osteochondral defects |
| Тип | paper |
| DOI | 10.1088/1758-5082/2/3/035004 |
| Electronic ISSN | 1758-5090 |
| Print ISSN | 1758-5082 |
| Журнал | Biofabrication |
| Том | 2 |
| Первая страница | 35004 |
| Последняя страница | 35015 |
| Аффилиация | Cohen, Daniel L; Cornell University, Mechanical and Aerospace Engineering, Ithaca, NY, USA |
| Аффилиация | Lipton, Jeffrey I; Cornell University, Mechanical and Aerospace Engineering, Ithaca, NY, USA |
| Аффилиация | Bonassar, Lawrence J; Cornell University, Mechanical and Aerospace Engineering, Ithaca, NY, USA; Cornell University, Biomedical Engineering, Ithaca, NY, USA |
| Аффилиация | Lipson, Hod; Cornell University, Mechanical and Aerospace Engineering, Ithaca, NY, USA; Cornell University, Faculty of Computing and Information Science, Ithaca, NY, USA; |
| Выпуск | 3 |
