| Автор | Khoda, A K M |
| Автор | Ozbolat, Ibrahim T |
| Автор | Koc, Bahattin |
| Дата выпуска | 2011-09-01 |
| dc.description | This paper presents a novel continuous tool-path planning methodology for hollowed scaffold fabrication in tissue engineering. A new functionally gradient porous architecture is proposed with a continuous material deposition planning scheme. A controllable variational pore size and hence the porosity have been achieved with a combination of two geometrically oriented consecutive layers. The desired porosity has been achieved with consecutive layers by geometrically partitioning each layer into sub-regions based on the area and the tissue scaffold design constraints. A continuous, interconnected and optimized tool-path for layers has been generated for a three-dimensional biomaterial deposition/printing process. A zigzag pattern tool-path has been proposed for an accumulated sub-region layer, and a concentric spiral-like optimal tool-path pattern has been generated for the successive layer to ensure continuity along the structure. Three-dimensional layers, formed by the proposed tool-path plan, vary the pore size and the porosity based on the biological and mechanical requirements. Several examples demonstrate the proposed methodology along with illustrative results. Also a comparative study between the proposed design and conventional Cartesian coordinate scaffolds has been performed. The results demonstrate a significant reduction in design error with the proposed method. Moreover, sample examples have been fabricated using a micro-nozzle biomaterial deposition system, and characterized for validation. |
| Формат | application.pdf |
| Издатель | Institute of Physics Publishing |
| Копирайт | 2011 IOP Publishing Ltd |
| Название | A functionally gradient variational porosity architecture for hollowed scaffolds fabrication |
| Тип | paper |
| DOI | 10.1088/1758-5082/3/3/034106 |
| Electronic ISSN | 1758-5090 |
| Print ISSN | 1758-5082 |
| Журнал | Biofabrication |
| Том | 3 |
| Первая страница | 34106 |
| Последняя страница | 34120 |
| Аффилиация | Khoda, A K M; Department of Industrial Engineering, University at Buffalo, Buffalo, NY 14260, USA |
| Аффилиация | Ozbolat, Ibrahim T; Department of Mechanical and Industrial Engineering, Center for Computer Aided Design, The University of Iowa, Iowa City, IA 52242-1527, USA |
| Аффилиация | Koc, Bahattin; Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, Turkey |
| Выпуск | 3 |
