| dc.description |
IN Nature of May 12, 1962, L. I. Woolf offered an explanation of â severeâ and â mildâ X-linked hæmophilia A while discussing gene expression in heterozygotes. He proposed that the plasma-level of antihæmophilic globulin (AHG, AHF, Factor VIII) regulated its rate of synthesis, that is, that â end-product (feedback) inhibitionâ controlled the synthetic rate. â Feedback inhibitionâ is known to be a very important regulatory mechanism in biosynthetic pathways, producing small anabolites such as amino-acids, vitamins, etc.<sup>1</sup>. We can find no documented evidence, however, that â feedback inhibitionâ is a controlling mechanism in protein synthesis. â Feedback inhibitionâ should be sharply distinguished in this respect from â feedback repressionâ , which is recognized to be a highly important genetic mechanism concerned with regulating the synthesis of enzymes (proteins) in bacteria<sup>1â 4</sup>. |
