| dc.description |
HISTAMINE, slow reacting substance in anaphylaxis (SRS-A) and prostaglandin F2α (PGF2α) are among substances obtained from lungs that contract human isolated bronchial muscle<sup>1â 4</sup>. Fenamates antagonize bronchoconstriction induced by SRS-A but not that induced by histamine, and they lessen anaphylactic bronchoconstriction in the guinea-pig in vivo<sup>5â 7</sup>. In view of the possibility, arising from these observations, that fenamates might be useful clinically against pathological bronchoconstriction, we explored how far meclofenamate (sodium N-(2,6-dichloro-m-tolyl) anthranilate)<sup>8</sup> and flufenamate (sodium N-(α,α,α-trifluoro-m-toryl) anthranilate)<sup>9</sup> antagonized the contraction of human isolated bronchial muscle induced by histamine, SRS-A or PGF2α. |
