Prolonged Clot Lysis Time and Absence of Platelet γM-globulin in Patients with Thrombasthenia
TAYLOR, FLETCHER B.; ZUCKER, MARJORIE B.
Журнал:
Nature
Дата:
1969
Аннотация:
THE presence of fibrinogen, γM-globulin, γG-globulin, albumin and plasminogen on or in normal washed platelets has been demonstrated by the use of specific antisera<sup>1â 4</sup>. Taylor and Müller-Eberhard<sup>4</sup> observed that blocking either fibrinogen or γM-globulin with specific antibody prevented normal retraction and lysis of dilute whole-blood clots prepared by the technique of Fearnley et al.<sup>4</sup>. Because platelets are also necessary for a normal response<sup>4</sup>, their studies suggested that the fibrinogen and γM-globulin adsorbed onto the platelets play an essential part in the process.
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