| Автор | KAMINSKI, M. |
| Автор | KAMINSKA, GRAZYNA |
| Автор | JAKOBISIAK, M. |
| Автор | BRZEZINSKI, W. |
| Дата выпуска | 1977 |
| dc.description | LYMPHOCYTE-induced angiogenesis (LIA) has been introduced by Sidky and Auerbach<sup>1</sup> as a quantitative and sensitive assay for measuring cell-mediated immunity in vivo. In this assay immuno-competent lymphocytes are injected intradermally into allogeneic or semiallogeneic mice. A local graft versus host (GVH) reaction is therefore induced, resulting in new blood vessel formation. As early as the second day post-injection, this effect could be observed in a doseâ response fashion dependent on the number of cells injected. The relationship of lymphocyte-induced angiogenesis to tumour-induced angiogenesis mediated by tumourâ angiogenesis factor (TAF)<sup>2</sup> remains theoretical. Folkman and others have demonstrated inhibition of TAF-induced angiogenesis by cartilage fragments<sup>3</sup> or extracts<sup>4</sup>. In this study we show that isolated chondrocytes can inhibit the angiogenesis induced by lymphocytes in vivo. Their ability to do so depends on the ratio of chondrocytes to lymphocytes used. |
| Формат | application.pdf |
| Название | Inhibition of lymphocyte-induced angiogenesis by isolated chondrocytes |
| Тип | LETTERS TO NATURE |
| DOI | 10.1038/268238a0 |
| Print ISSN | 0028-0836 |
| Журнал | Nature |
| Том | 268 |
| Первая страница | 238 |
| Последняя страница | 240 |
| Выпуск | 5617 |
