The International HapMap Project
Gibbs, Richard A.; Belmont, John W.; Hardenbol, Paul; Willis, Thomas D.; Yu, Fuli; Yang, Huanming; Ch'ang, Lan-Yang; Huang, Wei; Liu, Bin; Shen, Yan; Tam, Paul Kwong-Hang; Tsui, Lap-Chee; Waye, Mary Miu Yee; Wong, Jeffrey Tze-Fei; Zeng, Changqing; Zhang, Qingrun; Chee, Mark S.; Galver, Luana M.; Kruglyak, Semyon; Murray, Sarah S.; Oliphant, Arnold R.; Montpetit, Alexandre; Hudson, Thomas J.; Chagnon, Fanny; Ferretti, Vincent; Leboeuf, Martin; Phillips, Michael S.; Verner, Andrei; Kwok, Pui-Yan; Duan, Shenghui; Lind, Denise L.; Miller, Raymond D.; Rice, John P.; Saccone, Nancy L.; Taillon-Miller, Patricia; Xiao, Ming; Nakamura, Yusuke; Sekine, Akihiro; Sorimachi, Koki; Tanaka, Toshihiro; Tanaka, Yoichi; Tsunoda, Tatsuhiko; Yoshino, Eiji; Bentley, David R.; Deloukas, Panos; Hunt, Sarah; Powell, Don; Altshuler, David; Gabriel, Stacey B.; Zhang, Houcan; Zeng, Changqing; Matsuda, Ichiro; Fukushima, Yoshimitsu; Macer, Darryl R.; Suda, Eiko; Rotimi, Charles N.; Adebamowo, Clement A.; Aniagwu, Toyin; Marshall, Patricia A.; Matthew, Olayemi; Nkwodimmah, Chibuzor; Royal, Charmaine D. M.; Leppert, Mark F.; Dixon, Missy; Stein, Lincoln D.; Cunningham, Fiona; Kanani, Ardavan; Thorisson, Gudmundur A.; Chakravarti, Aravinda; Chen, Peter E.; Cutler, David J.; Kashuk, Carl S.; Donnelly, Peter; Marchini, Jonathan; McVean, Gilean A. T.; Myers, Simon R.; Cardon, Lon R.; Abecasis, Gonçalo R.; Morris, Andrew; Weir, Bruce S.; Mullikin, James C.; Sherry, Stephen T.; Feolo, Michael; Altshuler, David; Daly, Mark J.; Schaffner, Stephen F.; Qiu, Renzong; Kent, Alastair; Dunston, Georgia M.; Kato, Kazuto; Niikawa, Norio; Knoppers, Bartha M.; Foster, Morris W.; Clayton, Ellen Wright; Wang, Vivian Ota; Watkin, Jessica; Gibbs, Richard A.; Belmont, John W.; Sodergren, Erica; Weinstock, George M.; Wilson, Richard K.; Fulton, Lucinda L.; Rogers, Jane; Birren, Bruce W.; Han, Hua; Wang, Hongguang; Godbout, Martin; Wallenburg, John C.; L'Archevêque, Paul; Bellemare, Guy; Todani, Kazuo; Fujita, Takashi; Tanaka, Satoshi; Holden, Arthur L.; Lai, Eric H.; Collins, Francis S.; Brooks, Lisa D.; McEwen, Jean E.; Guyer, Mark S.; Jordan, Elke; Peterson, Jane L.; Spiegel, Jack; Sung, Lawrence M.; Zacharia, Lynn F.; Kennedy, Karen; Dunn, Michael G.; Seabrook, Richard; Shillito, Mark; Skene, Barbara; Stewart, John G.; Valle (chair), David L.; Clayton (co-chair), Ellen Wright; Jorde (co-chair), Lynn B.; Belmont, John W.; Chakravarti, Aravinda; Cho, Mildred K.; Duster, Troy; Foster, Morris W.; Jasperse, Marla; Knoppers, Bartha M.; Kwok, Pui-Yan; Licinio, Julio; Long, Jeffrey C.; Marshall, Patricia A.; Ossorio, Pilar N.; Wang, Vivian Ota; Rotimi, Charles N.; Royal, Charmaine D. M.; Spallone, Patricia; Terry, Sharon F.; Lander (chair), Eric S.; Lai (co-chair), Eric H.; Nickerson (co-chair), Deborah A.; Abecasis, Gonçalo R.; Altshuler, David; Bentley, David R.; Boehnke, Michael; Cardon, Lon R.; Daly, Mark J.; Deloukas, Panos; Douglas, Julie A.; Gabriel, Stacey B.; Hudson, Richard R.; Hudson, Thomas J.; Kruglyak, Leonid; Kwok, Pui-Yan; Nakamura, Yusuke; Nussbaum, Robert L.; Royal, Charmaine D. M.; Schaffner, Stephen F.; Sherry, Stephen T.; Stein, Lincoln D.; Tanaka, Toshihiro; â The International HapMap Consortium; Genotyping centres: Baylor College of Medicine and ParAllele BioScience; Chinese HapMap Consortium; Illumina; McGill University and Génome Québec Innovation Centre; University of California at San Francisco and Washington University; University of Tokyo and RIKEN; Wellcome Trust Sanger Institute; Whitehead Institute/MIT Center for Genome Research; Community engagement/public consultation and sample-collection groups: Beijing Normal University and Beijing Genomics Institute; Health Sciences University of Hokkaido, Eubios Ethics Institute and Shinshu University; Howard University and University of Ibadan; University of Utah; Analysis Groups: Cold Spring Harbor Laboratory; Johns Hopkins University School of Medicine; University of Oxford; University of Oxford, Wellcome Trust Centre for Human Genetics; US National Institutes of Health; Whitehead Institute/MIT Center for Genome Research; Ethical, Legal and Social Issues: Chinese Academy of Social Sciences; Genetic Interest Group; Howard University; Kyoto University; Nagasaki University; University of Montréal; University of Oklahoma; Vanderbilt University; Wellcome Trust; SNP Discovery: Baylor College of Medicine; Washington University; Wellcome Trust Sanger Institute; Whitehead Institute/MIT Center for Genome Research; Scientific Management: Chinese Academy of Sciences; Chinese Ministry of Science and Technology; Genome Canada; Génome Québec; Japanese Ministry of Education, Culture, Sports, Science and Technology; The SNP Consortium; US National Institutes of Health; Wellcome Trust; Initial Planning Groups: Populations and Ethical, Legal and Social Issues Group; Methods Group
Журнал:
Nature
Дата:
2003
Аннотация:
The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance our ability to choose targets for therapeutic intervention.
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