| Автор | Thorgeirsson, Thorgeir E. |
| Автор | Geller, Frank |
| Автор | Sulem, Patrick |
| Автор | Rafnar, Thorunn |
| Автор | Wiste, Anna |
| Автор | Magnusson, Kristinn P. |
| Автор | Manolescu, Andrei |
| Автор | Thorleifsson, Gudmar |
| Автор | Stefansson, Hreinn |
| Автор | Ingason, Andres |
| Автор | Stacey, Simon N. |
| Автор | Bergthorsson, Jon T. |
| Автор | Thorlacius, Steinunn |
| Автор | Gudmundsson, Julius |
| Автор | Jonsson, Thorlakur |
| Автор | Jakobsdottir, Margret |
| Автор | Saemundsdottir, Jona |
| Автор | Olafsdottir, Olof |
| Автор | Gudmundsson, Larus J. |
| Автор | Bjornsdottir, Gyda |
| Автор | Kristjansson, Kristleifur |
| Автор | Skuladottir, Halla |
| Автор | Isaksson, Helgi J. |
| Автор | Gudbjartsson, Tomas |
| Автор | Jones, Gregory T. |
| Автор | Mueller, Thomas |
| Автор | Gottsäter, Anders |
| Автор | Flex, Andrea |
| Автор | Aben, Katja K. H. |
| Автор | de Vegt, Femmie |
| Автор | Mulders, Peter F. A. |
| Автор | Isla, Dolores |
| Автор | Vidal, Maria J. |
| Автор | Asin, Laura |
| Автор | Saez, Berta |
| Автор | Murillo, Laura |
| Автор | Blondal, Thorsteinn |
| Автор | Kolbeinsson, Halldor |
| Автор | Stefansson, Jon G. |
| Автор | Hansdottir, Ingunn |
| Автор | Runarsdottir, Valgerdur |
| Автор | Pola, Roberto |
| Автор | Lindblad, Bengt |
| Автор | van Rij, Andre M. |
| Автор | Dieplinger, Benjamin |
| Автор | Haltmayer, Meinhard |
| Автор | Mayordomo, Jose I. |
| Автор | Kiemeney, Lambertus A. |
| Автор | Matthiasson, Stefan E. |
| Автор | Oskarsson, Hogni |
| Автор | Tyrfingsson, Thorarinn |
| Автор | Gudbjartsson, Daniel F. |
| Автор | Gulcher, Jeffrey R. |
| Автор | Jonsson, Steinn |
| Автор | Thorsteinsdottir, Unnur |
| Автор | Kong, Augustine |
| Автор | Stefansson, Kari |
| Дата выпуска | 2008 |
| dc.description | Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year. Evidence for genetic influence on smoking behaviour and nicotine dependence (ND) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health. Smoking is the major risk factor for lung cancer (LC) and is one of the main risk factors for peripheral arterial disease (PAD). Here we identify a common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking-related diseases in populations of European descent. The variant has an effect on the number of cigarettes smoked per day in our sample of smokers. The same variant was associated with ND in a previous genome-wide association study that used low-quantity smokers as controls, and with a similar approach we observe a highly significant association with ND. A comparison of cases of LC and PAD with population controls each showed that the variant confers risk of LC and PAD. The findings provide a case study of a geneâ environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases. |
| Формат | application.pdf |
| Издатель | Nature Publishing Group |
| Копирайт | Nature Publishing Group |
| Название | A variant associated with nicotine dependence, lung cancer and peripheral arterial disease |
| Тип | LETTERS TO NATURE |
| DOI | 10.1038/nature06846 |
| Print ISSN | 0028-0836 |
| Журнал | Nature |
| Том | 452 |
| Первая страница | 638 |
| Последняя страница | 642 |
| Аффилиация | Thorgeirsson, Thorgeir E.; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Geller, Frank; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Sulem, Patrick; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Rafnar, Thorunn; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Wiste, Anna; deCODE Genetics, 101 Reykjavik, Iceland; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA |
| Аффилиация | Magnusson, Kristinn P.; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Manolescu, Andrei; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Thorleifsson, Gudmar; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Stefansson, Hreinn; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Ingason, Andres; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Stacey, Simon N.; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Bergthorsson, Jon T.; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Thorlacius, Steinunn; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Gudmundsson, Julius; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Jonsson, Thorlakur; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Jakobsdottir, Margret; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Saemundsdottir, Jona; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Olafsdottir, Olof; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Gudmundsson, Larus J.; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Bjornsdottir, Gyda; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Kristjansson, Kristleifur; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Jones, Gregory T.; Department of Surgery, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand |
| Аффилиация | Mueller, Thomas; Department of Laboratory Medicine, Konventhospital Barmherzige Brueder, 4020 Linz, Austria |
| Аффилиация | Gottsäter, Anders; Center for Vascular Diseases, University Hospital, MAS, 205 02 Malmö, Sweden |
| Аффилиация | Flex, Andrea; Laboratory of Vascular Biology and Genetics, A. Gemelli University Hospital, Universita Cattolica del Sacro Cuore School of Medicine, 00168 Rome, Italy |
| Аффилиация | Aben, Katja K. H.; Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands; Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands |
| Аффилиация | de Vegt, Femmie; Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands |
| Аффилиация | Mulders, Peter F. A.; Department of Urology, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands |
| Аффилиация | Isla, Dolores; Division of Medical Oncology, University Hospital, 5009 Zaragoza, Spain |
| Аффилиация | Vidal, Maria J.; Division of Medical Oncology, University Hospital, 5009 Zaragoza, Spain |
| Аффилиация | Asin, Laura; Nanotechnology Institute of Aragon, 5009 Zaragoza, Spain |
| Аффилиация | Saez, Berta; Health Science Institute, 5009 Zaragoza, Spain |
| Аффилиация | Murillo, Laura; Division of Medical Oncology, Hospital Reina Sofia, 31500 Tudela, Spain |
| Аффилиация | Blondal, Thorsteinn; Department of Lung Disease, Primary Health Care Centre, 101 Reykjavik, Iceland |
| Аффилиация | Hansdottir, Ingunn; Vogur SAA Addiction Treatment Center, 112 Reykjavik, Iceland |
| Аффилиация | Runarsdottir, Valgerdur; Vogur SAA Addiction Treatment Center, 112 Reykjavik, Iceland |
| Аффилиация | Pola, Roberto; Laboratory of Vascular Biology and Genetics, A. Gemelli University Hospital, Universita Cattolica del Sacro Cuore School of Medicine, 00168 Rome, Italy; OASI Institute for Research and Care (IRCCS), 94018 Troina (EN), Italy |
| Аффилиация | Lindblad, Bengt; Center for Vascular Diseases, University Hospital, MAS, 205 02 Malmö, Sweden |
| Аффилиация | van Rij, Andre M.; Department of Surgery, Dunedin School of Medicine, University of Otago, Dunedin 9054, New Zealand |
| Аффилиация | Dieplinger, Benjamin; Department of Laboratory Medicine, Konventhospital Barmherzige Brueder, 4020 Linz, Austria |
| Аффилиация | Haltmayer, Meinhard; Department of Laboratory Medicine, Konventhospital Barmherzige Brueder, 4020 Linz, Austria |
| Аффилиация | Mayordomo, Jose I.; Division of Medical Oncology, University Hospital, 5009 Zaragoza, Spain; Nanotechnology Institute of Aragon, 5009 Zaragoza, Spain; Health Science Institute, 5009 Zaragoza, Spain |
| Аффилиация | Kiemeney, Lambertus A.; Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands; Comprehensive Cancer Center East, 6501 BG Nijmegen, The Netherlands; Department of Urology, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands |
| Аффилиация | Matthiasson, Stefan E.; School of Medicine, University of Iceland, 101 Reykjavik, Iceland |
| Аффилиация | Oskarsson, Hogni; Therapeia, 101 Reykjavik, Iceland |
| Аффилиация | Tyrfingsson, Thorarinn; Vogur SAA Addiction Treatment Center, 112 Reykjavik, Iceland |
| Аффилиация | Gudbjartsson, Daniel F.; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Gulcher, Jeffrey R.; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Thorsteinsdottir, Unnur; deCODE Genetics, 101 Reykjavik, Iceland; School of Medicine, University of Iceland, 101 Reykjavik, Iceland |
| Аффилиация | Kong, Augustine; deCODE Genetics, 101 Reykjavik, Iceland |
| Аффилиация | Stefansson, Kari; deCODE Genetics, 101 Reykjavik, Iceland; School of Medicine, University of Iceland, 101 Reykjavik, Iceland |
| Выпуск | 7187 |
