Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Ehret, Georg B.; Munroe, Patricia B.; Rice, Kenneth M.; Bochud, Murielle; Johnson, Andrew D.; Chasman, Daniel I.; Smith, Albert V.; Tobin, Martin D.; Verwoert, Germaine C.; Hwang, Shih-Jen; Pihur, Vasyl; Vollenweider, Peter; Oâ Reilly, Paul F.; Amin, Najaf; Bragg-Gresham, Jennifer L.; Teumer, Alexander; Glazer, Nicole L.; Launer, Lenore; Hua Zhao, Jing; Aulchenko, Yurii; Heath, Simon; Sõber, Siim; Parsa, Afshin; Luan, Jianâ an; Arora, Pankaj; Dehghan, Abbas; Zhang, Feng; Lucas, Gavin; Hicks, Andrew A.; Jackson, Anne U.; Peden, John F; Tanaka, Toshiko; Wild, Sarah H.; Rudan, Igor; Igl, Wilmar; Milaneschi, Yuri; Parker, Alex N.; Fava, Cristiano; Chambers, John C.; Fox, Ervin R.; Kumari, Meena; Jin Go, Min; van der Harst, Pim; Hong Linda Kao, Wen; Sjögren, Marketa; Vinay, D. G.; Alexander, Myriam; Tabara, Yasuharu; Shaw-Hawkins, Sue; Whincup, Peter H.; Liu, Yongmei; Shi, Gang; Kuusisto, Johanna; Tayo, Bamidele; Seielstad, Mark; Sim, Xueling; Hoang Nguyen, Khanh-Dung; Lehtimäki, Terho; Matullo, Giuseppe; Wu, Ying; Gaunt, Tom R.; Charlotte Onland-Moret, N.; Cooper, Matthew N.; Platou, Carl G. P.; Org, Elin; Hardy, Rebecca; Dahgam, Santosh; Palmen, Jutta; Vitart, Veronique; Braund, Peter S.; Kuznetsova, Tatiana; Uiterwaal, Cuno S. P. M.; Adeyemo, Adebowale; Palmas, Walter; Campbell, Harry; Ludwig, Barbara; Tomaszewski, Maciej; Tzoulaki, Ioanna; Palmer, Nicholette D.; Aspelund, Thor; Garcia, Melissa; Chang, Yen-Pei C.; Oâ Connell, Jeffrey R.; Steinle, Nanette I.; Grobbee, Diederick E.; Arking, Dan E.; Kardia, Sharon L.; Morrison, Alanna C.; Hernandez, Dena; Najjar, Samer; McArdle, Wendy L.; Hadley, David; Brown, Morris J.; Connell, John M.; Hingorani, Aroon D.; Day, Ian N.M.; Lawlor, Debbie A.; Beilby, John P.; Lawrence, Robert W.; Clarke, Robert; Hopewell, Jemma C.; Ongen, Halit; Dreisbach, Albert W.; Li, Yali; Hunter Young, J.; Bis, Joshua C.; Kähönen, Mika; Viikari, Jorma; Adair, Linda S.; Lee, Nanette R.; Chen, Ming-Huei; Olden, Matthias; Pattaro, Cristian; Hoffman Bolton, Judith A.; Köttgen, Anna; Bergmann, Sven; Mooser, Vincent; Chaturvedi, Nish; Frayling, Timothy M.; Islam, Muhammad; Jafar, Tazeen H.; Erdmann, Jeanette; Kulkarni, Smita R.; Bornstein, Stefan R.; Grässler, Jürgen; Groop, Leif; Voight, Benjamin F.; Kettunen, Johannes; Howard, Philip; Taylor, Andrew; Guarrera, Simonetta; Ricceri, Fulvio; Emilsson, Valur; Plump, Andrew; Barroso, Inês; Khaw, Kay-Tee; Weder, Alan B.; Hunt, Steven C.; Sun, Yan V.; Bergman, Richard N.; Collins, Francis S.; Bonnycastle, Lori L.; Scott, Laura J.; Stringham, Heather M.; Peltonen, Leena; Perola, Markus; Vartiainen, Erkki; Brand, Stefan-Martin; Staessen, Jan A.; Wang, Thomas J.; Burton, Paul R.; Soler Artigas, Maria; Dong, Yanbin; Snieder, Harold; Wang, Xiaoling; Zhu, Haidong; Lohman, Kurt K.; Rudock, Megan E.; Heckbert, Susan R.; Smith, Nicholas L.; Wiggins, Kerri L.; Doumatey, Ayo; Shriner, Daniel; Veldre, Gudrun; Viigimaa, Margus; Kinra, Sanjay; Prabhakaran, Dorairaj; Tripathy, Vikal; Langefeld, Carl D.; Rosengren, Annika; Thelle, Dag S.; Maria Corsi, Anna; Singleton, Andrew; Forrester, Terrence; Hilton, Gina; McKenzie, Colin A.; Salako, Tunde; Iwai, Naoharu; Kita, Yoshikuni; Ogihara, Toshio; Ohkubo, Takayoshi; Okamura, Tomonori; Ueshima, Hirotsugu; Umemura, Satoshi; Eyheramendy, Susana; Meitinger, Thomas; Wichmann, H.-Erich; Shin Cho, Yoon; Kim, Hyung-Lae; Lee, Jong-Young; Scott, James; Sehmi, Joban S.; Zhang, Weihua; Hedblad, Bo; Nilsson, Peter; Davey Smith, George; Wong, Andrew; Narisu, Narisu; StanÄ Ã¡ková, Alena; Raffel, Leslie J.; Yao, Jie; Kathiresan, Sekar; Oâ Donnell, Christopher J.; Schwartz, Stephen M.; Arfan Ikram, M.; Longstreth Jr, W. T.; Mosley, Thomas H.; Seshadri, Sudha; Shrine, Nick R.G.; Wain, Louise V.; Morken, Mario A.; Swift, Amy J.; Laitinen, Jaana; Prokopenko, Inga; Zitting, Paavo; Cooper, Jackie A.; Humphries, Steve E.; Danesh, John; Rasheed, Asif; Goel, Anuj; Hamsten, Anders; Watkins, Hugh; Bakker, Stephan J. L.; van Gilst, Wiek H.; Janipalli, Charles S.; Radha Mani, K.; Yajnik, Chittaranjan S.; Hofman, Albert; Mattace-Raso, Francesco U. S.; Oostra, Ben A.; Demirkan, Ayse; Isaacs, Aaron; Rivadeneira, Fernando; Lakatta, Edward G.; Orru, Marco; Scuteri, Angelo; Ala-Korpela, Mika; Kangas, Antti J.; Lyytikäinen, Leo-Pekka; Soininen, Pasi; Tukiainen, Taru; Würtz, Peter; Twee-Hee Ong, Rick; Dörr, Marcus; Kroemer, Heyo K.; Völker, Uwe; Völzke, Henry; Galan, Pilar; Hercberg, Serge; Lathrop, Mark; Zelenika, Diana; Deloukas, Panos; Mangino, Massimo; Spector, Tim D.; Zhai, Guangju; Meschia, James F.; Nalls, Michael A.; Sharma, Pankaj; Terzic, Janos; Kranthi Kumar, M. V.; Denniff, Matthew; Zukowska-Szczechowska, Ewa; Wagenknecht, Lynne E.; Gerald R. Fowkes, F.; Charchar, Fadi J.; Schwarz, Peter E. H.; Hayward, Caroline; Guo, Xiuqing; Rotimi, Charles; Bots, Michiel L.; Brand, Eva; Samani, Nilesh J.; Polasek, Ozren; Talmud, Philippa J.; Nyberg, Fredrik; Kuh, Diana; Laan, Maris; Hveem, Kristian; Palmer, Lyle J.; van der Schouw, Yvonne T.; Casas, Juan P.; Mohlke, Karen L.; Vineis, Paolo; Raitakari, Olli; Ganesh, Santhi K.; Wong, Tien Y.; Shyong Tai, E; Cooper, Richard S.; Laakso, Markku; Rao, Dabeeru C.; Harris, Tamara B.; Morris, Richard W.; Dominiczak, Anna F.; Kivimaki, Mika; Marmot, Michael G.; Miki, Tetsuro; Saleheen, Danish; Chandak, Giriraj R.; Coresh, Josef; Navis, Gerjan; Salomaa, Veikko; Han, Bok-Ghee; Zhu, Xiaofeng; Kooner, Jaspal S.; Melander, Olle; Ridker, Paul M; Bandinelli, Stefania; Gyllensten, Ulf B.; Wright, Alan F.; Wilson, James F.; Ferrucci, Luigi; Farrall, Martin; Tuomilehto, Jaakko; Pramstaller, Peter P.; Elosua, Roberto; Soranzo, Nicole; Sijbrands, Eric J. G.; Altshuler, David; Loos, Ruth J. F.; Shuldiner, Alan R.; Gieger, Christian; Meneton, Pierre; Uitterlinden, Andre G.; Wareham, Nicholas J.; Gudnason, Vilmundur; Rotter, Jerome I.; Rettig, Rainer; Uda, Manuela; Strachan, David P.; Witteman, Jacqueline C. M.; Hartikainen, Anna-Liisa; Beckmann, Jacques S.; Boerwinkle, Eric; Vasan, Ramachandran S.; Boehnke, Michael; Larson, Martin G.; Järvelin, Marjo-Riitta; Psaty, Bruce M.; Abecasis, Gonçalo R.; Chakravarti, Aravinda; Elliott, Paul; van Duijn, Cornelia M.; Newton-Cheh, Christopher; Levy, Daniel; Caulfield, Mark J.; Johnson, Toby; The International Consortium for Blood Pressure Genome-Wide Association Studies; Ehret, Georg B.; ; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Bugnon 17, 1005 Lausanne, Switzerland.;; Munroe, Patricia B.; Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Bochud, Murielle; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Bugnon 17, 1005 Lausanne, Switzerland.; Johnson, Andrew D.; ;; Chasman, Daniel I.; ;; Smith, Albert V.; Icelandic Heart Association, 201 Kópavogur, Iceland.; University of Iceland, 101 Reykajvik, Iceland.; Tobin, Martin D.; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK.; Verwoert, Germaine C.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), Netherland Genome Initiative (NGI), Erasmus 3000 CA Rotterdam, The Netherlands.; Hwang, Shih-Jen; ;; Center for Population Studies, National Heart Lung, and Blood Institute, Bethesda, Maryland 20824, USA.; Vollenweider, Peter; Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.; Oâ Reilly, Paul F.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.; Amin, Najaf; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Bragg-Gresham, Jennifer L.; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan 48103, USA.; Teumer, Alexander; Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany.; Glazer, Nicole L.; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA.; Launer, Lenore; Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.; Hua Zhao, Jing; MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.; Aulchenko, Yurii; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Heath, Simon; Centre National de Génotypage, Commissariat à Lâ Energie Atomique, Institut de Génomique, 91057 Evry, France.; Sõber, Siim; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia.; Luan, Jianâ an; MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.; Dehghan, Abbas; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), Netherland Genome Initiative (NGI), Erasmus 3000 CA Rotterdam, The Netherlands.; Chambers, John C.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.; Shaw-Hawkins, Sue; Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Org, Elin; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia.; Aspelund, Thor; Icelandic Heart Association, 201 Kópavogur, Iceland.; University of Iceland, 101 Reykajvik, Iceland.; Garcia, Melissa; Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.; Bis, Joshua C.; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA.; Lee, Nanette R.; Office of Population Studies Foundation, University of San Carlos, Talamban, Cebu City 6000, Philippines.; Peltonen, Leena; ;;;; Burton, Paul R.; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK.; Soler Artigas, Maria; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK.; Smith, Nicholas L.; ;; Veldre, Gudrun; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia.; Department of Cardiology, University of Tartu, L. Puusepa 8, 51014 Tartu, Estonia.; Viigimaa, Margus; Tallinn University of Technology, Institute of Biomedical Engineering, Ehitajate tee 5, 19086 Tallinn, Estonia.; Centre of Cardiology, North Estonia Medical Centre, Sütiste tee 19, 13419 Tallinn, Estonia.; Forrester, Terrence; Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica.; McKenzie, Colin A.; Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica.; Salako, Tunde; University of Ibadan, 200284 Ibadan, Nigeria.; Eyheramendy, Susana; Department of Statistics, Pontificia Universidad Catolica de Chile, Vicuña Mackena 4860, Santiago, Chile.; Wichmann, H.-Erich; ;; Zhang, Weihua; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.; Oâ Donnell, Christopher J.; ;; Arfan Ikram, M.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), Netherland Genome Initiative (NGI), Erasmus 3000 CA Rotterdam, The Netherlands.; Shrine, Nick R.G.; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK.; Wain, Louise V.; Department of Health Sciences, University of Leicester, University Rd, Leicester LE1 7RH, UK.; Hofman, Albert; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Mattace-Raso, Francesco U. S.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Demirkan, Ayse; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Isaacs, Aaron; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Rivadeneira, Fernando; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Ala-Korpela, Mika; ;; Tukiainen, Taru; ;; Würtz, Peter; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.;; Twee-Hee Ong, Rick; ;; Völker, Uwe; Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany.; Lathrop, Mark; Centre National de Génotypage, Commissariat à Lâ Energie Atomique, Institut de Génomique, 91057 Evry, France.; Zelenika, Diana; Centre National de Génotypage, Commissariat à Lâ Energie Atomique, Institut de Génomique, 91057 Evry, France.; Terzic, Janos; Faculty of Medicine, University of Split, 21000 Split, Croatia.; Zukowska-Szczechowska, Ewa; Department of Internal Medicine, Diabetology, and Nephrology, Medical University of Silesia, 41-800, Zabrze, Poland.; Polasek, Ozren; Department of Medical Statistics, Epidemiology and Medical Informatics, Andrija Stampar School of Public Health, University of Zagreb, 10000 Zagreb, Croatia.; Laan, Maris; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, Tartu 51010, Estonia.; Shyong Tai, E; ;; Harris, Tamara B.; Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.; Ridker, Paul M; ;; Tuomilehto, Jaakko; ;;; Sijbrands, Eric J. G.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Loos, Ruth J. F.; MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.; Uitterlinden, Andre G.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), Netherland Genome Initiative (NGI), Erasmus 3000 CA Rotterdam, The Netherlands.; Wareham, Nicholas J.; MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.; Gudnason, Vilmundur; Icelandic Heart Association, 201 Kópavogur, Iceland.; University of Iceland, 101 Reykajvik, Iceland.; Witteman, Jacqueline C. M.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Netherlands Consortium for Healthy Aging (NCHA), Netherland Genome Initiative (NGI), Erasmus 3000 CA Rotterdam, The Netherlands.; Järvelin, Marjo-Riitta; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.;;;; Psaty, Bruce M.; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA.;; Abecasis, Gonçalo R.; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan 48103, USA.; Elliott, Paul; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.;; van Duijn, Cornelia M.; Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.; Centre of Medical Systems Biology (CMSB 1-2), NGI Erasmus Medical Center, Rotterdam, The Netherlands.; Newton-Cheh, Christopher; ;; Levy, Daniel; ;; Center for Population Studies, National Heart Lung, and Blood Institute, Bethesda, Maryland 20824, USA.; Caulfield, Mark J.; Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Johnson, Toby; Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Журнал:
Nature
Дата:
2011
Аннотация:
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (â ¥140â mmâ Hg systolic blood pressure orâ â ¥90â mmâ Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3â GUCY1B3, NPR3â C5orf23, ADM, FURINâ FES, GOSR2, GNASâ EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
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Andrew; Campbell, Peter J.; Vincent-Salomon, Anne; Richardson, Andrea L.; Reis-Filho, Jorge S.; van de Vijver, Marc; Thomas, Gilles; Masson-Jacquemier, Jocelyne D.; Aparicio, Samuel; Borg, Ake; Børresen-Dale, Anne-Lise; Caldas, Carlos; Foekens, John A.; Stunnenberg, Hendrik G.; vanâ t Veer, Laura; Easton, Douglas F.; Spellman, Paul T.; Martin, Sancha; Barker, Anna D.; Chin, Lynda; Collins, Francis S.; Compton, Carolyn C.; Ferguson, Martin L.; Gerhard, Daniela S.; Getz, Gad; Gunter, Chris; Guttmacher, Alan; Guyer, Mark; Hayes, D. Neil; Lander, Eric S.; Ozenberger, Brad; Penny, Robert; Peterson, Jane; Sander, Chris; Shaw, Kenna M.; Speed, Terence P.; Spellman, Paul T.; Vockley, Joseph G.; Wheeler, David A.; Wilson, Richard K.; Hudson (Chairperson), Thomas J.; Chin, Lynda; Knoppers, Bartha M.; Lander, Eric S.; Lichter, Peter; Stein, Lincoln D.; Stratton, Michael R.; Anderson, Warwick; Barker, Anna D.; Bell, Cindy; Bobrow, Martin; Burke, Wylie; Collins, Francis S.; Compton, Carolyn C.; DePinho, Ronald A.; Easton, Douglas F.; Futreal, P. Andrew; Gerhard, Daniela S.; Green, Anthony R.; Guyer, Mark; Hamilton, Stanley R.; Hubbard, Tim J.; Kallioniemi, Olli P.; Kennedy, Karen L.; Ley, Timothy J.; Liu, Edison T.; Lu, Youyong; Majumder, Partha; Marra, Marco; Ozenberger, Brad; Peterson, Jane; Schafer, Alan J.; Spellman, Paul T.; Stunnenberg, Hendrik G.; Wainwright, Brandon J.; Wilson, Richard K.; Yang, Huanming; The International Cancer Genome Consortium; Executive committee; Ethics and policy committee; Tissue and clinical annotation working group; Technologies working group; Bioinformatics analyses working group; Data coordination and management working group; Data release, data tiers and publications working group; Data coordination centre; International data access committee; Cancer genome projects: Pancreatic cancer (ductal adenocarcinoma) and ovarian cancer (serous adenocarcinoma) (Australia); Pancreatic cancer (ductal adenocarcinomas) (Canada); Gastric cancer (intestinal- and diffuse-type) (China); Renal cancer (renal cell carcinoma; focus on but not limited to clear cell subtype) (European Union/France); Breast cancer (subtypes defined by an amplification of ER+ HER ductal-type) (European Union/United Kingdom); Breast cancer (subtype defined by an amplification of the HER2 gene) (France); Liver cancer (hepatocellular carcinoma; secondary to alcohol and adiposity) (France); Paediatric brain tumours (medulloblastoma, paediatric pilocytic astrocytoma) (Germany); Oral cancer (gingivobuccal) (India); Rare pancreatic tumours (enteropancreatic endocrine tumours and rare pancreatic exocrine tumours; intraductal papillary mucinous neoplasms, solid pseudopapillary tumours, mucinous cystic neoplasms and other rarer tumours) (Italy); Liver cancer (hepatocellular carcinoma; virus associated) (Japan); Chronic lymphocytic leukaemia (with mutated and unmutated IgVH) (Spain); Breast cancer (triple negative/lobular/other) (United Kingdom); The Cancer Genome Atlas (United States); Initial scientific planning committee (Macmillan Publishers Limited. 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Burton, Paul R.; Clayton, David G.; Cardon, Lon R.; Craddock, Nick; Deloukas, Panos; Duncanson, Audrey; Kwiatkowski, Dominic P.; McCarthy, Mark I.; Ouwehand, Willem H.; Samani, Nilesh J.; Todd, John A.; Donnelly, Peter; Barrett, Jeffrey C.; Burton, Paul R.; Davison, Dan; Donnelly, Peter; Easton, Doug; Evans, David; Leung, Hin-Tak; Marchini, Jonathan L.; Morris, Andrew P.; Spencer, Chris C. A.; Tobin, Martin D.; Cardon, Lon R.; Clayton, David G.; Attwood, Antony P.; Boorman, James P.; Cant, Barbara; Everson, Ursula; Hussey, Judith M.; Jolley, Jennifer D.; Knight, Alexandra S.; Koch, Kerstin; Meech, Elizabeth; Nutland, Sarah; Prowse, Christopher V.; Stevens, Helen E.; Taylor, Niall C.; Walters, Graham R.; Walker, Neil M.; Watkins, Nicholas A.; Winzer, Thilo; Todd, John A.; Ouwehand, Willem H.; Jones, Richard W.; McArdle, Wendy L.; Ring, Susan M.; Strachan, David P.; Pembrey, Marcus; Breen, Gerome; St Clair, David; Caesar, Sian; Gordon-Smith, Katherine; Jones, Lisa; Fraser, Christine; Green, Elaine K.; Grozeva, Detelina; Hamshere, Marian L.; Holmans, Peter A.; Jones, Ian R.; Kirov, George; Moskvina, Valentina; Nikolov, Ivan; O'Donovan, Michael C.; Owen, Michael J.; Craddock, Nick; Collier, David A.; Elkin, Amanda; Farmer, Anne; Williamson, Richard; McGuffin, Peter; Young, Allan H.; Ferrier, I. Nicol; Ball, Stephen G.; Balmforth, Anthony J.; Barrett, Jennifer H.; Bishop, D. Timothy; Iles, Mark M.; Maqbool, Azhar; Yuldasheva, Nadira; Hall, Alistair S.; Braund, Peter S.; Burton, Paul R.; Dixon, Richard J.; Mangino, Massimo; Stevens, Suzanne; Tobin, Martin D.; Thompson, John R.; Samani, Nilesh J.; Bredin, Francesca; Tremelling, Mark; Parkes, Miles; Drummond, Hazel; Lees, Charles W.; Nimmo, Elaine R.; Satsangi, Jack; Fisher, Sheila A.; Forbes, Alastair; Lewis, Cathryn M.; Onnie, Clive M.; Prescott, Natalie J.; Sanderson, Jeremy; Mathew, Christopher G.; Barbour, Jamie; Mohiuddin, M. Khalid; Todhunter, Catherine E.; Mansfield, John C.; Ahmad, Tariq; Cummings, Fraser R.; Jewell, Derek P.; Webster, John; Brown, Morris J.; Clayton, David G.; Lathrop, G. Mark; Connell, John; Dominiczak, Anna; Samani, Nilesh J.; Marcano, Carolina A. Braga; Burke, Beverley; Dobson, Richard; Gungadoo, Johannie; Lee, Kate L.; Munroe, Patricia B.; Newhouse, Stephen J.; Onipinla, Abiodun; Wallace, Chris; Xue, Mingzhan; Caulfield, Mark; Farrall, Martin; Barton, Anne; and Genomics (BRAGGS), The Biologics in RA Genetics; Bruce, Ian N.; Donovan, Hannah; Eyre, Steve; Gilbert, Paul D.; Hider, Samantha L.; Hinks, Anne M.; John, Sally L.; Potter, Catherine; Silman, Alan J.; Symmons, Deborah P. M.; Thomson, Wendy; Worthington, Jane; Clayton, David G.; Dunger, David B.; Nutland, Sarah; Stevens, Helen E.; Walker, Neil M.; Widmer, Barry; Todd, John A.; Frayling, Timothy M.; Freathy, Rachel M.; Lango, Hana; Perry, John R. B.; Shields, Beverley M.; Weedon, Michael N.; Hattersley, Andrew T.; Hitman, Graham A.; Walker, Mark; Elliott, Kate S.; Groves, Christopher J.; Lindgren, Cecilia M.; Rayner, Nigel W.; Timpson, Nicholas J.; Zeggini, Eleftheria; McCarthy, Mark I.; Newport, Melanie; Sirugo, Giorgio; Lyons, Emily; Vannberg, Fredrik; Hill, Adrian V. S.; Bradbury, Linda A.; Farrar, Claire; Pointon, Jennifer J.; Wordsworth, Paul; Brown, Matthew A.; Franklyn, Jayne A.; Heward, Joanne M.; Simmonds, Matthew J.; Gough, Stephen C. L.; Seal, Sheila; Susceptibility Collaboration (UK), Breast Cancer; Stratton, Michael R.; Rahman, Nazneen; Ban, Maria; Goris, An; Sawcer, Stephen J.; Compston, Alastair; Conway, David; Jallow, Muminatou; Newport, Melanie; Sirugo, Giorgio; Rockett, Kirk A.; Kwiatkowski, Dominic P.; Bumpstead, Suzannah J.; Chaney, Amy; Downes, Kate; Ghori, Mohammed J. R.; Gwilliam, Rhian; Hunt, Sarah E.; Inouye, Michael; Keniry, Andrew; King, Emma; McGinnis, Ralph; Potter, Simon; Ravindrarajah, Rathi; Whittaker, Pamela; Widden, Claire; Withers, David; Deloukas, Panos; Leung, Hin-Tak; Nutland, Sarah; Stevens, Helen E.; Walker, Neil M.; Todd, John A.; Easton, Doug; Clayton, David G.; Burton, Paul R.; Tobin, Martin D.; Barrett, Jeffrey C.; Evans, David; Morris, Andrew P.; Cardon, Lon R.; Cardin, Niall J.; Davison, Dan; Ferreira, Teresa; Pereira-Gale, Joanne; Hallgrimsdóttir, Ingileif B.; Howie, Bryan N.; Marchini, Jonathan L.; Spencer, Chris C. A.; Su, Zhan; Teo, Yik Ying; Vukcevic, Damjan; Donnelly, Peter; Bentley, David; Brown, Matthew A.; Cardon, Lon R.; Caulfield, Mark; Clayton, David G.; Compston, Alistair; Craddock, Nick; Deloukas, Panos; Donnelly, Peter; Farrall, Martin; Gough, Stephen C. L.; Hall, Alistair S.; Hattersley, Andrew T.; Hill, Adrian V. S.; Kwiatkowski, Dominic P.; Mathew, Christopher G.; McCarthy, Mark I.; Ouwehand, Willem H.; Parkes, Miles; Pembrey, Marcus; Rahman, Nazneen; Samani, Nilesh J.; Stratton, Michael R.; Todd, John A.; Worthington, Jane; The Wellcome Trust Case Control Consortium; Management Committee; Data and Analysis Committee; UK Blood Services and University of Cambridge Controls; 1958 Birth Cohort Controls; Bipolar Disorder; Coronary Artery Disease; Crohnâ s Disease; Hypertension; Rheumatoid Arthritis; Type 1 Diabetes; Type 2 Diabetes; Tuberculosis; Ankylosing Spondylitis; Autoimmune Thyroid Disease; Breast Cancer; Multiple Sclerosis; Gambian Controls; DNA, Genotyping, Data QC and Informatics; Statistics; Primary Investigators (Nature Publishing Group, 2007)
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Nejentsev, Sergey; Howson, Joanna M. M.; Walker, Neil M.; Szeszko, Jeffrey; Field, Sarah F.; Stevens, Helen E.; Reynolds, Pamela; Hardy, Matthew; King, Erna; Masters, Jennifer; Hulme, John; Maier, Lisa M.; Smyth, Deborah; Bailey, Rebecca; Cooper, Jason D.; Ribas, Gloria; Campbell, R. Duncan; Clayton, David G.; Todd, John A.; Burton, Paul R.; Clayton, David G.; Cardon, Lon R.; Craddock, Nick; Deloukas, Panos; Duncanson, Audrey; Kwiatkowski, Dominic P.; McCarthy, Mark I.; Ouwehand, Willem H.; Samani, Nilesh J.; Todd, John A.; Donnelly, Peter; Barrett, Jeffrey C.; Burton, Paul R.; Davison, Dan; Donnelly, Peter; Easton, Doug; Evans, David; Leung, Hin-Tak; Marchini, Jonathan L.; Morris, Andrew P.; Spencer, Chris C. A.; Tobin, Martin D.; Cardon, Lon R.; Clayton, David G.; Attwood, Antony P.; Boorman, James P.; Cant, Barbara; Everson, Ursula; Hussey, Judith M.; Jolley, Jennifer D.; Knight, Alexandra S.; Koch, Kerstin; Meech, Elizabeth; Nutland, Sarah; Prowse, Christopher V.; Stevens, Helen E.; Taylor, Niall C.; Walters, Graham R.; Walker, Neil M.; Watkins, Nicholas A.; Winzer, Thilo; Todd, John A.; Ouwehand, Willem H.; Jones, Richard W.; McArdle, Wendy L.; Ring, Susan M.; Strachan, David P.; Pembrey, Marcus; Breen, Gerome; St Clair , David; Caesar, Sian; Gordon-Smith, Katherine; Jones, Lisa; Fraser, Christine; Green, Elaine K.; Grozeva, Detelina; Hamshere, Marian L.; Holmans, Peter A.; Jones, Ian R.; Kirov, George; Moskvina, Valentina; Nikolov, Ivan; Oâ Donovan, Michael C.; Owen, Michael J.; Craddock, Nick; Collier, David A.; Elkin, Amanda; Farmer, Anne; Williamson, Richard; McGuffin, Peter; Young, Allan H.; Nicol Ferrier, I.; Ball, Stephen G.; Balmforth, Anthony J.; Barrett, Jennifer H.; Bishop, D. Timothy; Iles, Mark M.; Maqbool, Azhar; Yuldasheva, Nadira; Hall, Alistair S.; Braund, Peter S.; Burton, Paul R.; Dixon, Richard J.; Mangino, Massimo; Stevens, Suzanne; Tobin, Martin D.; Thompson, John R.; Samani, Nilesh J.; Bredin, Francesca; Tremelling, Mark; Parkes, Miles; Drummond, Hazel; Lees, Charles W.; Nimmo, Elaine R.; Satsangi, Jack; Fisher, Sheila A.; Forbes, Alastair; Lewis, Cathryn M.; Onnie, Clive M.; Prescott, Natalie J.; Sanderson, Jeremy; Mathew, Christopher G.; Barbour, Jamie; Khalid Mohiuddin, M.; Todhunter, Catherine E.; Mansfield, John C.; Ahmad, Tariq; Cummings, Fraser R.; Jewell, Derek P.; Webster, John; Brown, Morris J.; Clayton, David G.; Lathrop, G. Mark; Connell, John; Dominiczak, Anna; Samani, Nilesh J.; Braga, Carolina A.; Burke, Beverley; Dobson, Richard; Gungadoo, Johannie; Lee, Kate L.; Munroe, Patricia B.; Newhouse, Stephen J.; Onipinla, Abiodun; Wallace, Chris; Xue, Mingzhan; Caulfield, Mark; Farrall, Martin; Barton, Anne; Bruce, Ian N.; Donovan, Hannah; Eyre, Steve; Gilbert, Paul D.; Hider, Samantha L.; Hinks, Anne M.; John, Sally L.; Potter, Catherine; Silman, Alan J.; Symmons, Deborah P. M.; Thomson, Wendy; Worthington, Jane; Clayton, David G.; Dunger, David B.; Nutland, Sarah; Stevens, Helen E.; Walker, Neil M.; Widmer, Barry; Todd, John A.; Frayling, Timothy M.; Freathy, Rachel M.; Lango, Hana; Perry, John R. B.; Shields, Beverley M.; Weedon, Michael N.; Hattersley, Andrew T.; Hitman, Graham A.; Walker, Mark; Elliott, Kate S.; Groves, Christopher J.; Lindgren, Cecilia M.; Rayner, Nigel W.; Timpson, Nicholas J.; Zeggini, Eleftheria; McCarthy, Mark I.; Newport, Melanie; Sirugo, Giorgio; Lyons, Emily; Vannberg, Fredrik; Hill, Adrian V. S.; Bradbury, Linda A.; Farrar, Claire; Pointon, Jennifer J.; Wordsworth, Paul; Brown, Matthew A.; Franklyn, Jayne A.; Heward, Joanne M.; Simmonds, Matthew J.; Gough, Stephen C. L.; Seal, Sheila; Stratton, Michael R.; Rahman, Nazneen; Ban, Maria; Goris, An; Sawcer, Stephen J.; Compston, Alastair; Conway, David; Jallow, Muminatou; Newport, Melanie; Sirugo, Giorgio; Rockett, Kirk A.; Kwiatkowski, Dominic P.; Bryan, Claire; Bumpstead, Suzannah J.; Chaney, Amy; Downes, Kate; Ghori, Jilur; Gwilliam, Rhian; Hunt, Sarah E.; Inouye, Michael; Keniry, Andrew; King, Emma; McGinnis, Ralph; Potter, Simon; Ravindrarajah, Rathi; Whittaker, Pamela; Withers, David; Deloukas, Panos; Leung, Hin-Tak; Nutland, Sarah; Stevens, Helen E.; Walker, Neil M.; Todd, John A.; Easton, Doug; Clayton, David G.; Burton, Paul R.; Tobin, Martin D.; Barrett, Jeffrey C.; Evans, David; Morris, Andrew P.; Cardon, Lon R.; Cardin, Niall J.; Davison, Dan; Ferreira, Teresa; Pereira-Gale, Joanne; Hallgrimsdóttir, Ingeleif B.; Howie, Bryan N.; Marchini, Jonathan L.; Spencer, Chris C. A.; Su, Zhan; Ying Teo, Yik; Vukcevic, Damjan; Donnelly , Peter; Bentley, David; Brown, Matthew A.; Cardon, Lon R.; Caulfield, Mark; Clayton, David G.; Compston, Alistair; Craddock, Nick; Deloukas, Panos; Donnelly, Peter; Farrall, Martin; Gough, Stephen C. L.; Hall, Alistair S.; Hattersley, Andrew T.; Hill, Adrian V. S.; Kwiatkowski, Dominic P.; Mathew, Christopher G.; McCarthy, Mark I.; Ouwehand, Willem H.; Parkes, Miles; Pembrey, Marcus; Rahman, Nazneen; Samani, Nilesh J.; Stratton, Michael R.; Todd, John A.; Worthington, Jane; The Wellcome Trust Case Control Consortium; Management committee; Analysis committee; UK blood services and University of Cambridge controls; 1958 birth cohort controls; Bipolar disorder; Coronary artery disease; Crohnâ s disease; Hypertension; Rheumatoid arthritis; The Biologics in RA Genetics and Genomics Study Syndicate (BRAGGS) Steering Committee; Type 1 diabetes; Type 2 diabetes; Tuberculosis; Ankylosing spondylitis; Autoimmune thyroid disease; Breast cancer; Breast Cancer Susceptibility Collaboration (UK); Multiple sclerosis; Gambian controls; DNA, genotyping, data QC and informatics; Statistics; Primary investigators; Nejentsev, Sergey; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Howson, Joanna M. M.; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Walker, Neil M.; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Szeszko, Jeffrey; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Field, Sarah F.; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Stevens, Helen E.; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Reynolds, Pamela; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Hardy, Matthew; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; King, Erna; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Masters, Jennifer; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Hulme, John; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Maier, Lisa M.; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Smyth, Deborah; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Bailey, Rebecca; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Cooper, Jason D.; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Ribas, Gloria; MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, CB10 1SB, UK; Campbell, R. Duncan; MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, CB10 1SB, UK; Department of Physiology Anatomy and Genetics, University of Oxford, OX1 3QX, UK; Clayton, David G.; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK; Todd, John A.; Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK (Nature Publishing Group, 2007)