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Журнал Science по автору "Aaronson SA"

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  • Reynolds SH; Stowers SJ; Patterson RM; Maronpot RR; Aaronson SA; Anderson MW (American Association for the Advancement of Science, 1987-9-11)
    The validity of mouse liver tumor end points in assessing the potential hazards of chemical exposure to humans is a controversial but important issue, since liver neoplasia in mice is the most frequent tumor target tissue ...
  • King CR; Kraus MH; Aaronson SA (American Association for the Advancement of Science, 1985-9-6)
    The cellular gene encoding the receptor for epidermal growth factor (EGF) has considerable homology to the oncogene of avian erythroblastosis virus. In a human mammary carcinoma, a DNA sequence was identified that is related ...
  • Callahan R; Chiu IM; Wong JF; Tronick; Roe BA; Aaronson SA; Schlom J (American Association for the Advancement of Science, 1985-6-7)
    Human DNA contains multiple copies of a novel class of endogenous retroviral genomes. Analysis of a human recombinant DNA clone (HLM-2) containing one such proviral genome revealed that it is a mosaic of retroviral-related ...
  • Kruh GD; King CR; Kraus MH; Popescu NC; Amsbaugh SC; McBride WO; Aaronson SA (American Association for the Advancement of Science, 1986-12-19)
    A DNA sequence related to the abl proto-oncogene was identified in human placenta. Molecular cloning and nucleotide sequence analysis revealed two putative exons whose predicted amino acid sequence was most homologous to ...
  • Devare SG; Stephenson JR; Sarma PS; Aaronson SA; Charder S (American Association for the Advancement of Science, 1976-12-24)
    A highly sensitive and specific radioimmunoassay has been developed for the major structural protein of an oncornavirus etiologically associated with bovine lymphosarcoma. This test can be used to identify cattle which ...
  • Beckmann MP; Betsholtz C; Heldin CH; Westermark B; Di Marco E; Di Fiore PP; Robbins KC; Aaronson SA (American Association for the Advancement of Science, 1988-9-9)
    Human platelet-derived growth factor (PDGF) consists of two distinct but related polypeptide chains designated PDGF-A and PDGF-B. The gene encoding PDGF-B has given rise to the v-sis oncogene. In the present study the ...
  • Reddy EP; Smith MJ; Aaronson SA (American Association for the Advancement of Science, 1981-10-23)
    The complete nucleotide sequence of a mammalian transforming retrovirus. Moloney murine sarcoma virus, has been determined. MSV, recombinant virus derived of helper viral and cellular sequences, possesses termini resembling ...
  • Nagao K; Yokoro K; Aaronson SA (American Association for the Advancement of Science, 1981-4-17)
    Nonadherent tissue culture cell lines were established from normal bone marrow of a variety of mouse strains. The lines possessed morphological and histochemical markers of the basophil/mast cell and contained committed ...
  • Di Fiore PP; Segatto O; Taylor WG; Aaronson SA; Pierce JH (American Association for the Advancement of Science, 1990-4-6)
    The epidermal growth factor (EGF) receptor (EGFR) can efficiently couple with mitogenic signaling pathways when it is transfected into interleukin-3 (IL-3)-dependent 32D hematopoietic cells. When expression vectors for ...
  • Di Fiore PP; Pierce JH; Kraus MH; Segatto O; King CR; Aaronson SA (American Association for the Advancement of Science, 1987-7-10)
    A wide variety of human tumors contain an amplified or overexpressed erbB-2 gene, which encodes a growth factor receptor-like protein. When erbB-2 complementary DNA was expressed in NIH/3T3 cells under the control of the ...
  • Leal F; Williams LT; Robbins KC; Aaronson SA (American Association for the Advancement of Science, 1985-10-18)
    A scheme for partial purification of biologically active v-sis-coded protein from cells transformed with simian sarcoma virus (SSV) has made possible a functional comparison of the transforming protein with platelet-derived ...
  • Andersen PR; Barbacid M; Tronick; Clark HF; Aaronson SA (American Association for the Advancement of Science, 1979-4-20)
    A retrovirus previously isolated from a tumored Russell's viper is shown by molecular hybridization to be an endogenous virus of this reptilian species. Radio-immunologic techniques revealed that the viper retrovirus is ...
  • Miki T; Fleming TP; Bottaro DP; Rubin JS; Ron D; Aaronson SA (American Association for the Advancement of Science, 1991-1-4)
    An expression cloning strategy was devised to isolate the keratinocyte growth factor (KGF) receptor complementary DNA. NIH/3T3 fibroblasts, which secrete this epithelial cell-specific mitogen, were transfected with a ...
  • Eva A; Aaronson SA (American Association for the Advancement of Science, 1983-5-27)
    The DNA's from two of four methylcholanthrene-induced mouse fibrosarcomas contained transforming genes that were identical in their pattern of restriction endonuclease resistance to inactivation of biologic activity. This ...
  • Aaronson SA (American Association for the Advancement of Science, 1991-11-22)
    Signaling pathways that mediate the normal functions of growth factors are commonly subverted in cancer. Oncogenes identified by a variety of approaches have been shown to function at critical steps in mitogenic signaling. ...
  • Finch PW; Rubin JS; Miki T; Ron D; Aaronson SA (American Association for the Advancement of Science, 1989-8-18)
    Keratinocyte growth factor (KGF) is a human mitogen that is specific for epithelial cells. The complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast growth factor family. The KGF transcript ...
  • Chan AM; Rubin JS; Bottaro DP; Hirschfield DW; Chedid M; Aaronson SA (American Association for the Advancement of Science, 1991-11-29)
    We identified a naturally occurring hepatocyte growth factor (HGF) variant, whose predicted sequence extends only through the second kringle domain of this plasminogen-related molecule. This smaller molecule, derived from ...
  • Bottaro DP; Rubin JS; Faletto DL; Chan AM; Kmiecik TE; Vande Woude GF; Aaronson SA (American Association for the Advancement of Science, 1991-2-15)
    Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells ...
  • Robbins KC; Devare SG; Reddy EP; Aaronson SA (American Association for the Advancement of Science, 1982-12-10)
    Simian sarcoma virus (SSV) deletion mutants were constructed from a molecular clone containing the entire infectious provirus. Transfection analysis of these mutants localized the SSV transforming gene to a small region ...
  • Wang LM; Myers MG; Sun XJ; Aaronson SA; White M; Pierce JH (American Association for the Advancement of Science, 1993-9-17)
    Although several interleukin-3 (IL-3)-dependent cell lines proliferate in response to IL-4 or insulin, the 32D line does not. Insulin and IL-4 sensitivity was restored to 32D cells by expression of IRS-1, the principal ...