| Автор | Kreuz, David S. |
| Автор | Axelrod, Julius |
| Дата выпуска | 1974 |
| dc.description | A sensitive and specific enzymatic-isotopic method of determining plasma amphetamine concentrations in man is described. The assay is based on the transfer of the tritiated methyl group of S-adenosyl-L-[methyl-<sup>3</sup>H]methionine to amphetamine in the presence of a partially purified N-methyltransferase from rabbit lung. With this assay as little as 10 nanograms of amphetamine per milliliter of plasma can be accurately determined. The concentrations of d- and 1-amphetamine in the plasma after 20 to 30 milligrams of the drug had been ingested by human subjects are reported. |
| Формат | application.pdf |
| Издатель | American Association for the Advancement of Science |
| Копирайт | 1974 by the American Association for the Advancement of Science |
| Тема | REPORTS |
| Название | Amphetamine in Human Plasma: A Sensitive and Specific Enzymatic Assay |
| Тип | research-article |
| Electronic ISSN | 1095-9203 |
| Print ISSN | 0036-8075 |
| Журнал | Science |
| Том | 183 |
| Первая страница | 420 |
| Последняя страница | 421 |
| Аффилиация | Pharmacology-Toxicology Program, National Institute of General Medical Sciences, Bethesda, Maryland 20014 |
| Аффилиация | Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014 |
| Выпуск | 4123 |
| Библиографическая ссылка | ANGGARD, E, GAS CHROMATOGRAPHIC DETERMINATION OF AMPHETAMINE IN BLOOD, TISSUE, AND URINE, SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 26: 137 (1970). |
| Библиографическая ссылка | ARNOLD, L.E., LEVOAMPHETAMINE AND DEXTROAMPHETAMINE - DIFFERENTIAL EFFECT ON AGGRESSION AND HYPERKINESIS IN CHILDREN AND DOGS, AMERICAN JOURNAL OF PSYCHIATRY 130: 165 (1973). |
| Библиографическая ссылка | AXELROD, J, ENZYMATIC N-METHYLATION OF SEROTONIN AND OTHER AMINES, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 138: 28 (1962). |
| Библиографическая ссылка | GRIFFITH, J.D., AMPHETAMINES RELATED (1970). |
| Библиографическая ссылка | LEBISH, P, DETERMINATION OF AMPHETAMINE, METHAMPHETAMINE, AND RELATED AMINES IN BLOOD AND URINE BY GAS CHROMATOGRAPHY WITH HYDROGEN-FLAME IONIZATION DETECTOR, CLINICAL CHEMISTRY 16: 195 (1970). |
| Библиографическая ссылка | MODELL, W, STATUS AND PROSPECT OF DRUGS FOR OVEREATING, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 173: 1131 (1960). |
| Библиографическая ссылка | NARASIMHACHARI, N, GAS-LIQUID CHROMATOGRAPHY AND MASS-SPECTROMETRY OF BIOGENIC-AMINES AND AMPHETAMINES AS THEIR ISOTHIOCYANATE DERIVATIVES, ANALYTICAL BIOCHEMISTRY 45: 154 (1972). |
| Библиографическая ссылка | PRINZMETAL, M, The use of benzedrine for the treatment of narcolepsy, JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 105: 2051 (1935). |
| Библиографическая ссылка | SNYDER, S.H., CATECHOLAMINES IN BRAIN AS MEDIATORS OF AMPHETAMINE PSYCHOSIS, ARCHIVES OF GENERAL PSYCHIATRY 27: 169 (1972). |
| Библиографическая ссылка | WENDER, P, MINIMAL BRAIN DYSFUN (1971). |
| Библиографическая ссылка | WINSBERG, B.G., AM J PSYCHIAT 128: 109 (1972). |
