| Автор | Van THIEL, David H. |
| Автор | Gavaler, Judith |
| Автор | Lester, Roger |
| Дата выпуска | 1974 |
| dc.description | Vitanin A (retinol) is essential for spermatogenesis. Alcohol dehydrogenase, the enzyme responsible for ethanol metabolism, is also required for the conversion of retinol to bioactive retinal at the end organ site. Ethanol inhibits the oxidation of retinol by testicular homogenates containing alcohol dehydrogenase. Thus, a possible biochemnical mechanism for the sterility of chronic alcoholics is identified. |
| Формат | application.pdf |
| Издатель | American Association for the Advancement of Science |
| Копирайт | 1974 by the American Association for the Advancement of Science |
| Тема | REPORTS |
| Название | Ethanol Inhibition of Vitamin A Metabolism in the Testes: Possible Mechanism for Sterility in Alcoholics |
| Тип | research-article |
| Electronic ISSN | 1095-9203 |
| Print ISSN | 0036-8075 |
| Журнал | Science |
| Том | 186 |
| Первая страница | 941 |
| Последняя страница | 942 |
| Аффилиация | Division of Gastroenterology, Department of Medicine, University of Pittsburgh, School of Medicine, Pittsbutrgh, Pennsylvania 15261 |
| Выпуск | 4167 |
| Библиографическая ссылка | 1 SECR HEW SPEC REP (1971). |
| Библиографическая ссылка | BENNETT, H.S., THE TESTIS, BREAST AND PROSTATE OF MEN WHO DIE OF CIRRHOSIS OF THE LIVER, AMERICAN JOURNAL OF CLINICAL PATHOLOGY 20: 814 (1950). |
| Библиографическая ссылка | BONNICHSEN, R.K., LIVER ALCOHOL DEHYDROGENASE, METHODS IN ENZYMOLOGY 1: 495 (1955). |
| Библиографическая ссылка | CHAUSEN, S.W., J AM MED ASSOC 111: 144 (1938). |
| Библиографическая ссылка | EVANS, H.M., Testicular degeneration due to inadequate vitamin A in cases where E is adequate, AMERICAN JOURNAL OF PHYSIOLOGY 99: 477 (1932). |
| Библиографическая ссылка | LEATHEM, J.H., TESTES 3: 188 (1970). |
| Библиографическая ссылка | LLOYD, C.W., ENDOCRINE CHANGES ASSOCIATED WITH LAENNECS CIRRHOSIS OF THE LIVER, AMERICAN JOURNAL OF MEDICINE 4: 315 (1948). |
| Библиографическая ссылка | MEZEY, E, INHIBITORY EFFECT OF ETHANOL ON RETINOL OXIDATION BY HUMAN LIVER AND CATTLE RETINA, EXPERIMENTAL AND MOLECULAR PATHOLOGY 15: 148 (1971). |
| Библиографическая ссылка | MORRIONE, T.G., Effect of estrogens on the testis in hepatic insufficiency, ARCHIVES OF PATHOLOGY 37: 39 (1944). |
| Библиографическая ссылка | PATEK, A.J., The occurrence of abnormal dark adaptation and its relation to vitamin A metabolism in patients with cirrhosis of the liver, JOURNAL OF CLINICAL INVESTIGATION 18: 609 (1939). |
| Библиографическая ссылка | RATHER, L.J., HEPATIC CIRRHOSIS AND TESTICULAR ATROPHY, ARCHIVES OF INTERNAL MEDICINE 80: 397 (1947). |
| Библиографическая ссылка | STEINBERGER, A, STIMULATORY EFFECT OF VITAMINS AND GLUTAMINE ON DIFFERENTIATION OF GERM CELLS IN RAT TESTES ORGAN CULTURE GROWN IN CHEMICALLY DEFINED MEDIA, EXPERIMENTAL CELL RESEARCH 44: 429 (1966). |
| Библиографическая ссылка | STEINBERGER, E, GONADS 715 (1969). |
| Библиографическая ссылка | VANTHIEL, D.H., IN PRESS. |
