| Автор | Wong, GL |
| Автор | Luben, RA |
| Автор | Cohn, DV |
| Дата выпуска | 1977 |
| dc.description | The actions of 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] and parathormone, both effective bone-resorptive agents in vivo and in vitro, were tested on CT (osteoclast-like) and PT (osteoblast-like) bone cells maintained in culture. Both agents stimulated acid phosphatase activity and hyaluronate synthesis in the CT cells and decreased alkaline phosphatase, citrate decarboxylation, and collagen synthesis in the PT cells. Calcitonin inhibited the changes induced in the CT but not in the PT cells. The activity of 1,25-(OH)2D3 differed from that of parathormone in one key respect: it did not increase cellular cyclic adenosine monophosphate, whereas parathormone did. Prior incubation of the bone cells with 1,25-(OH)2D3 for 6 to 24 hours made the cells refractory to the effect of parathormone on cyclic adenosine monophosphate formation. These data suggest that 1,25-(OH)2D3 and parathormone induce bone resorption by affecting the same cell types (osteoblasts and osteoclasts) although at different cellular sites. |
| Формат | application.pdf |
| Издатель | American Association for the Advancement of Science |
| Тема | articles |
| Название | 1,25-dihydroxycholecalciferol and parathormone: effects on isolated osteoclast-like and osteoblast-like cells |
| Тип | other |
| Electronic ISSN | 1095-9203 |
| Print ISSN | 0036-8075 |
| Журнал | Science |
| Том | 197 |
| Первая страница | 663 |
| Последняя страница | 665 |
| Выпуск | 4304 |
| Библиографическая ссылка | RECENT PROG HORM RES 27: 479 (1971). |
| Библиографическая ссылка | CARLSSON, A, ACTA PHYSIOL SCAND 35: 54 (1954). |
| Библиографическая ссылка | CHEN, T.C., ROLE OF VITAMIN-D METABOLITES IN PHOSPHATE TRANSPORT OF RAT INTESTINE, JOURNAL OF NUTRITION 104: 1056 (1974). |
| Библиографическая ссылка | CHU, LLH, BIOASSAY FOR PARATHYROID HORMONE BASED ON HORMONAL INHIBITION OF CO2 PRODUCTION FROM CITRATE IN MOUSE CALVARIUM, ENDOCRINOLOGY 89: 1425 (1971). |
| Библиографическая ссылка | CLARK, I, PARATHYROIDS 183 (1961). |
| Библиографическая ссылка | DELUCA, H.F., METABOLISM AND MECHANISM OF ACTION OF VITAMIN-D1, ANNUAL REVIEW OF BIOCHEMISTRY 45: 631 (1976). |
| Библиографическая ссылка | DELUCA, H.F., VITAM HORM 25: 315 (1967). |
| Библиографическая ссылка | HARRISON, H.E., SODIUM, POTASSIUM, AND INTESTINAL TRANSPORT OF GLUCOSE, L-TYROSINE, PHOSPHATE, AND CALCIUM, AMERICAN JOURNAL OF PHYSIOLOGY 205: 107 (1963). |
| Библиографическая ссылка | HARRISON, H.E., PARATHYROID HORMONE AND VITAMIN D, YALE JOURNAL OF BIOLOGY AND MEDICINE 38: 393 (1966). |
| Библиографическая ссылка | HARRISON, M.T., INTERRELATIONSHIPS OF VITAMIN D + PARATHYROID HORMONE IN CALCIUM HOMEOSTASIS, POSTGRADUATE MEDICAL JOURNAL 40: 497 (1964). |
| Библиографическая ссылка | HAUSSLER, M.R., METABOLISM OF VITAMIN-D3 IN CHICK, JOURNAL OF BIOLOGICAL CHEMISTRY 247: 2328 (1972). |
| Библиографическая ссылка | HEERSCHE, J.N., CALCIUM PARATHYROID 5111 (1972). |
| Библиографическая ссылка | HELLER, M, CELLULAR TRANSFORMATIONS IN MAMMALIAN BONES INDUCED BY PARATHYROID EXTRACT, AMERICAN JOURNAL OF ANATOMY 87: 315 (1950). |
| Библиографическая ссылка | JOHNSTON, C.C., BONE MATRIX BIOSYNTHESIS IN VITRO .2. EFFECTS OF PARATHYROID HORMONE, JOURNAL OF BIOLOGICAL CHEMISTRY 237: 3560 (1962). |
| Библиографическая ссылка | KOWARSKI, S, EFFECTS OF VITAMIN D ON PHOSPHATE TRANSPORT AND INCORPORATION INTO MUCOSAL CONSTITUENTS OF RAT INTESTINAL MUCOSA, JOURNAL OF BIOLOGICAL CHEMISTRY 244: 211 (1969). |
| Библиографическая ссылка | LAWSON, DEM, INTRANUCLEAR LOCALIZATION AND RECEPTOR PROTEINS FOR 1,25-DIHYDROXYCHOLECALCIFEROL IN CHICK INTESTINE, BIOCHEMICAL JOURNAL 144: 573 (1974). |
| Библиографическая ссылка | LUBEN, R.A., EFFECTS OF PARATHORMONE AND CALCITONIN ON CITRATE AND HYALURONATE METABOLISM IN CULTURED BONE, ENDOCRINOLOGY 98: 413 (1976). |
| Библиографическая ссылка | LUBEN, R.A., BIOCHEMICAL CHARACTERIZATION WITH PARATHORMONE AND CALCITONIN OF ISOLATED BONE-CELLS - PROVISIONAL IDENTIFICATION OF OSTEOCLASTS AND OSTEOBLASTS, ENDOCRINOLOGY 99: 526 (1976). |
| Библиографическая ссылка | NICHOLS, G, ACTA PHYSL SCAND 57: 51 (1963). |
| Библиографическая ссылка | RAISZ, L.G., 1,25-DIHYDROXYCHOLECALCIFEROL - POTENT STIMULATOR OF BONE RESORPTION IN TISSUE-CULTURE, SCIENCE 175: 768 (1972). |
| Библиографическая ссылка | REMOLDODONNELL, E, STIMULATION AND DESENSITIZATION OF MACROPHAGE ADENYLATE CYCLASE BY PROSTAGLANDINS AND CATECHOLAMINES, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 3615 (1974). |
| Библиографическая ссылка | STERN, P.H., BONE RESORBING ACTIVITIES OF 24-HYDROXY STEREOISOMERS OF 24-HYDROXYVITAMIN D3 AND 24,25-DIHYDROXYVITAMIN D3, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 67: 965 (1975). |
| Библиографическая ссылка | TANAKA, Y, BONE MINERAL MOBILIZATION ACTIVITY OF 1,25-DIHYDROXYCHOLECALCIFEROL, A METABOLITE OF VITAMIN-D, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 146: 574 (1971). |
| Библиографическая ссылка | TSAI, H.C., STUDIES ON CALCIFEROL METABOLISM - .8. EVIDENCE FOR A CYTOPLASMIC RECEPTOR FOR 1,25-DIHYDROXY-VITAMIN D3 IN INTESTINAL-MUCOSA, JOURNAL OF BIOLOGICAL CHEMISTRY 248: 5967 (1973). |
| Библиографическая ссылка | WASSERMAN, R.H., INTESTINAL-ABSORPTION OF PHOSPHATE IN CHICK - EFFECT OF VITAMIN-D3 AND OTHER PARAMETERS, JOURNAL OF NUTRITION 103: 586 (1973). |
| Библиографическая ссылка | WONG, G, SEPARATION OF PARATHYROID-HORMONE AND CALCITONIN-SENSITIVE CELLS FROM NON-RESPONSIVE BONE-CELLS, NATURE 252: 713 (1974). |
| Библиографическая ссылка | WONG, G.L., INHIBITION BY PARATHORMONE OF COLLAGEN SECRETION BY CULTURED OSTEOBLASTS, FEDERATION PROCEEDINGS 35: 1692 (1976). |
| Библиографическая ссылка | WONG, G.L., TARGET-CELLS IN BONE FOR PARATHORMONE AND CALCITONIN ARE DIFFERENT - ENRICHMENT FOR EACH CELL TYPE BY SEQUENTIAL DIGESTION OF MOUSE CALVARIA AND SELECTIVE ADHESION TO POLYMERIC SURFACES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 3167 (1975). |
