| Автор | Tsoukas, CD |
| Автор | Provvedini, DM |
| Автор | Manolagas, SC |
| Дата выпуска | 1984 |
| dc.description | The hormonal form of vitamin D3, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], at picomolar concentrations, inhibited the growth-promoting lymphokine interleukin-2, which is produced by human T lymphocytes activated in vitro by the mitogen phytohemagglutinin. Other metabolites of vitamin D3 were less effective than 1,25(OH)2D3 in suppressing interleukin-2; their order of potency corresponded to their respective affinity for the 1,25(OH)2D3 receptor, suggesting that the effect on interleukin-2 was mediated by this specific receptor. The proliferation of mitogen-activated lymphocytes was also inhibited by 1,25(OH)2D3. This effect of the hormone became more pronounced at later stages of the culture. These findings demonstrate that 1,25(OH)2D3 is an immunoregulatory hormone. |
| Формат | application.pdf |
| Издатель | American Association for the Advancement of Science |
| Тема | articles |
| Название | 1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone |
| Тип | other |
| Electronic ISSN | 1095-9203 |
| Print ISSN | 0036-8075 |
| Журнал | Science |
| Том | 224 |
| Первая страница | 1438 |
| Последняя страница | 1440 |
| Выпуск | 4656 |
| Библиографическая ссылка | ABE, E, DIFFERENTIATION OF MOUSE MYELOID-LEUKEMIA CELLS INDUCED BY 1-ALPHA,25-DIHYDROXYVITAMIN-D3, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78: 4990 (1981). |
| Библиографическая ссылка | BHALLA, A.K., SPECIFIC HIGH-AFFINITY RECEPTORS FOR 1,25-DIHYDROXYVITAMIN-D3 IN HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS - PRESENCE IN MONOCYTES AND INDUCTION IN LYMPHOCYTES-T FOLLOWING ACTIVATION, JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 57: 1308 (1983). |
| Библиографическая ссылка | CUPPS, T.R., CORTICOSTEROID-MEDIATED IMMUNOREGULATION IN MAN, IMMUNOLOGICAL REVIEWS 65: 133 (1982). |
| Библиографическая ссылка | DELUCA, H.F., VITAMIN-D SYSTEM IN THE REGULATION OF CALCIUM AND PHOSPHORUS-METABOLISM, NUTRITION REVIEWS 37: 161 (1979). |
| Библиографическая ссылка | HAUSSLER, M.R., ANN NY ACAD SCI 372: 502 (1981). |
| Библиографическая ссылка | HAUSSLER, M.R., BASIC AND CLINICAL CONCEPTS RELATED TO VITAMIN-D METABOLISM AND ACTION .1., NEW ENGLAND JOURNAL OF MEDICINE 297: 974 (1977). |
| Библиографическая ссылка | HAUSSLER, M.R., BASIC AND CLINICAL CONCEPTS RELATED TO VITAMIN-D METABOLISM AND ACTION .2., NEW ENGLAND JOURNAL OF MEDICINE 297: 1041 (1977). |
| Библиографическая ссылка | LICHTMAN, A.H., THE ROLE OF CALCIUM IN LYMPHOCYTE-PROLIFERATION - AN INTERPRETIVE REVIEW, BLOOD 61: 413 (1983). |
| Библиографическая ссылка | MANOLAGAS, S.C., HIGHLY SPECIFIC BINDING OF 1,25-DIHYDROXYCHOLECALCIFEROL IN BONE CYTOSOL, JOURNAL OF ENDOCRINOLOGY 80: 35 (1979). |
| Библиографическая ссылка | NORMAN, A.W., THE VITAMIN-D ENDOCRINE SYSTEM - STEROID-METABOLISM, HORMONE RECEPTORS, AND BIOLOGICAL RESPONSE (CALCIUM-BINDING PROTEINS), ENDOCRINE REVIEWS 3: 331 (1982). |
| Библиографическая ссылка | PROSCAL, D.A., AM J CLIN NUTR 29: 1271 (1976). |
| Библиографическая ссылка | PROVVEDINI, D.M., 1,25-DIHYDROXYVITAMIN D3 RECEPTORS IN HUMAN-LEUKOCYTES, SCIENCE 221: 1181 (1983). |
| Библиографическая ссылка | ROCKLIN, R.E., ADV IMMUNOL 29: 55 (1980). |
| Библиографическая ссылка | SIMPSON, R.U., CHARACTERIZATION OF A RECEPTOR-LIKE PROTEIN FOR 1,25-DIHYDROXYVITAMIN-D3 IN RAT SKIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 77: 5822 (1980). |
| Библиографическая ссылка | SMITH, K.A., T-CELL GROWTH-FACTOR AND THE CULTURE OF CLONED FUNCTIONAL T-CELLS, ADVANCES IN IMMUNOLOGY 31: 137 (1981). |
| Библиографическая ссылка | STERN, P, A MONOLOG ON ANALOGS - INVITRO EFFECTS OF VITAMIN-D METABOLITES AND CONSIDERATION OF THE MINERALIZATION QUESTION, CALCIFIED TISSUE INTERNATIONAL 33: 1 (1981). |
