| Автор | Lee, MS |
| Автор | Chang, KS |
| Автор | Cabanillas, F |
| Автор | Freireich, EJ |
| Автор | Trujillo, JM |
| Автор | Stass, SA |
| Дата выпуска | 1987 |
| dc.description | By means of the polymerase chain reaction (PCR) technique, DNA sequences were amplified that flank the crossover sites of a characteristic chromosomal translocation for follicular lymphomas, t(14;18)(q32;q21). This technique permitted the detection of cells carrying the t(14;18) hybrid DNA sequences at a dilution of 1:100,000. The remission marrow and blood samples of a patient with follicular lymphoma and the t(14;18) failed to show any abnormality by morphological examination and conventional Southern blot analysis. However, the t(14;18) hybrid DNA sequences were detected by the PCR technique. Thus, this technique is a highly sensitive tool to detect minimal residual cells carrying the t(14;18) and has the potential to identify a subpopulation of patients with subclinical disease. |
| Формат | application.pdf |
| Издатель | American Association for the Advancement of Science |
| Тема | articles |
| Название | Detection of minimal residual cells carrying the t(14;18) by DNA sequence amplification |
| Тип | other |
| Electronic ISSN | 1095-9203 |
| Print ISSN | 0036-8075 |
| Журнал | Science |
| Том | 237 |
| Первая страница | 175 |
| Последняя страница | 178 |
| Выпуск | 4811 |
| Библиографическая ссылка | BAKHSHI, A, CLONING THE CHROMOSOMAL BREAKPOINT OF T(14-18) HUMAN LYMPHOMAS - CLUSTERING AROUND JH ON CHROMOSOME-14 AND NEAR A TRANSCRIPTIONAL UNIT ON 18, CELL 41: 899 (1985). |
| Библиографическая ссылка | BLOOMFIELD, C.D., NONRANDOM CHROMOSOME-ABNORMALITIES IN LYMPHOMA, CANCER RESEARCH 43: 2975 (1983). |
| Библиографическая ссылка | CLEARY, M.L., CLONING AND STRUCTURAL-ANALYSIS OF CDNAS FOR BCL-2 AND A HYBRID BCL-2/IMMUNOGLOBULIN TRANSCRIPT RESULTING FROM THE T(14-18) TRANSLOCATION, CELL 47: 19 (1986). |
| Библиографическая ссылка | CLEARY, M.L., IMMUNOGLOBULIN GENE REARRANGEMENT AS A DIAGNOSTIC CRITERION OF BETA-CELL LYMPHOMA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 593 (1984). |
| Библиографическая ссылка | CLEARY, M.L., NUCLEOTIDE-SEQUENCE OF A T(14,18) CHROMOSOMAL BREAKPOINT IN FOLLICULAR LYMPHOMA AND DEMONSTRATION OF A BREAKPOINT-CLUSTER REGION NEAR A TRANSCRIPTIONALLY ACTIVE LOCUS ON CHROMOSOME-18, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 7439 (1985). |
| Библиографическая ссылка | FUKUHARA, S, CHROMOSOME-ABNORMALITIES IN POORLY DIFFERENTIATED LYMPHOCYTIC LYMPHOMA, CANCER RESEARCH 39: 3119 (1979). |
| Библиографическая ссылка | HU, E, DETECTION OF B-CELL LYMPHOMA IN PERIPHERAL-BLOOD BY DNA HYBRIDIZATION, LANCET 2: 1092 (1985). |
| Библиографическая ссылка | LEE, M.S., IN PRESS BLOOD. |
| Библиографическая ссылка | RAVETCH, J.V., STRUCTURE OF THE HUMAN-IMMUNOGLOBULIN MU LOCUS - CHARACTERIZATION OF EMBRYONIC AND REARRANGED J-GENE AND D-GENE, CELL 27: 583 (1981). |
| Библиографическая ссылка | SAIKI, R.K., ENZYMATIC AMPLIFICATION OF BETA-GLOBIN GENOMIC SEQUENCES AND RESTRICTION SITE ANALYSIS FOR DIAGNOSIS OF SICKLE-CELL ANEMIA, SCIENCE 230: 1350 (1985). |
| Библиографическая ссылка | SMITH, B.R., CIRCULATING MONOCLONAL LYMPHOCYTES-B IN NON-HODGKINS LYMPHOMA, NEW ENGLAND JOURNAL OF MEDICINE 311: 1476 (1984). |
| Библиографическая ссылка | TSUJIMOTO, Y, ANALYSIS OF THE STRUCTURE, TRANSCRIPTS, AND PROTEIN PRODUCTS OF BCL-2, THE GENE INVOLVED IN HUMAN FOLLICULAR LYMPHOMA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 5214 (1986). |
| Библиографическая ссылка | TSUJIMOTO, Y, CLONING OF THE CHROMOSOME BREAKPOINT OF NEOPLASTIC B-CELLS WITH THE T(14-18) CHROMOSOME-TRANSLOCATION, SCIENCE 226: 1097 (1984). |
| Библиографическая ссылка | TSUJIMOTO, Y, INVOLVEMENT OF THE BCL-2 GENE IN HUMAN FOLLICULAR LYMPHOMA, SCIENCE 228: 1440 (1985). |
| Библиографическая ссылка | TSUJIMOTO, Y, THE T(14,18) CHROMOSOME TRANSLOCATIONS INVOLVED IN B-CELL NEOPLASMS RESULT FROM MISTAKES IN VDJ JOINING, SCIENCE 229: 1390 (1985). |
| Библиографическая ссылка | YUNIS, J.J., DISTINCTIVE CHROMOSOMAL-ABNORMALITIES IN HISTOLOGIC SUBTYPES OF NON-HODGKINS LYMPHOMA, NEW ENGLAND JOURNAL OF MEDICINE 307: 1231 (1982). |
