| Автор | Morrison, NA |
| Автор | Shine, J |
| Автор | Fragonas, JC |
| Автор | Verkest, V |
| Автор | McMenemy, ML |
| Автор | Eisman, JA |
| Дата выпуска | 1989 |
| dc.description | The active hormonal form of vitamin D3, 1,25-dihydroxyvitamin D3[1,25(OH), which regulates cellular replication and function in many tissues and has a role in bone and calcium homeostasis, acts through a hormone receptor homologous with other steroid and thyroid hormone receptors. A 1,25(OH)2D3-responsive element (VDRE), which is within the promoter for osteocalcin [a bone protein induced by 1,25(OH)2D3] is unresponsive to other steroid hormones, can function in a heterologous promoter, and contains a doubly palindromic DNA sequence (TTGGTGACTCACCGGGTGAAC; -513 to -493 bp), with nucleotide sequence homology to other hormone responsive elements. The potent glucocorticoid repression of 1,25(OH)2D3 induction and of basal activity of this promoter acts through a region between -196 and +34 bp, distinct from the VDRE. |
| Формат | application.pdf |
| Издатель | American Association for the Advancement of Science |
| Тема | articles |
| Название | 1,25-dihydroxyvitamin D-responsive element and glucocorticoid repression in the osteocalcin gene |
| Тип | other |
| Electronic ISSN | 1095-9203 |
| Print ISSN | 0036-8075 |
| Журнал | Science |
| Том | 246 |
| Первая страница | 1158 |
| Последняя страница | 1161 |
| Выпуск | 4934 |
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