| Автор | Liou, HC |
| Автор | Boothby, MR |
| Автор | Finn, PW |
| Автор | Davidon, R |
| Автор | Nabavi, N |
| Автор | Zeleznik-Le, NJ |
| Автор | Ting, JP |
| Автор | Glimcher, LH |
| Дата выпуска | 1990 |
| dc.description | Several mutants derived from transformed human B cell lines are defective in expressing major histocompatibility complex (MHC) class II genes. The failure to express a class II gene in at least one such mutant line has been mapped to the MHC class II X box, a conserved transcriptional element in the promoter region. A complementary DNA encoding a DNA-binding protein (human X box binding protein, hXBP-1) whose target is the human DR alpha X box and the 3' flanking region has now been cloned. This complementary DNA encoded a protein with structural similarities to the c-jun proto-oncogene product, and its target sequence was closely related to the palindromic target sequence of c-jun. Mutation of the hXBP-1 DNA target sequence decreased DR alpha promoter activity in vivo. These studies suggest that the hXBP-1 protein acts as a transcription factor in B cells. |
| Формат | application.pdf |
| Издатель | American Association for the Advancement of Science |
| Тема | articles |
| Название | A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter |
| Тип | other |
| Electronic ISSN | 1095-9203 |
| Print ISSN | 0036-8075 |
| Журнал | Science |
| Том | 247 |
| Первая страница | 1581 |
| Последняя страница | 1584 |
| Выпуск | 4950 |
| Библиографическая ссылка | BASTA, P.V., IDENTIFICATION OF AN INTERFERON-GAMMA RESPONSE REGION 5' OF THE HUMAN HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN DR-ALPHA CHAIN GENE WHICH IS ACTIVE IN HUMAN GLIOBLASTOMA-MULTIFORME LINES, JOURNAL OF IMMUNOLOGY 138: 1275 (1987). |
| Библиографическая ссылка | BOOTHBY, M, DIFFERENCES IN DNA-SEQUENCE SPECIFICITY AMONG MHC CLASS-II X-BOX BINDING-PROTEINS, JOURNAL OF IMMUNOLOGY 142: 1005 (1989). |
| Библиографическая ссылка | CALMAN, A.F., EVIDENCE FOR A TRANS-ACTING FACTOR THAT REGULATES THE TRANSCRIPTION OF CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX GENES - GENETIC AND FUNCTIONAL-ANALYSIS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 8830 (1988). |
| Библиографическая ссылка | CHIU, R, THE C-FOS PROTEIN INTERACTS WITH C-JUN/AP-1 TO STIMULATE TRANSCRIPTION OF AP-1 RESPONSIVE GENES, CELL 54: 541 (1988). |
| Библиографическая ссылка | DORN, A, A MULTIPLICITY OF CCAAT BOX-BINDING PROTEINS, CELL 50: 863 (1987). |
| Библиографическая ссылка | DORN, A, CONSERVED MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II BOX-X AND BOX-Y ARE TRANSCRIPTIONAL CONTROL ELEMENTS AND SPECIFICALLY BIND NUCLEAR PROTEINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 6249 (1987). |
| Библиографическая ссылка | HUYNH, T.V., DNA CLONING 1: (1985). |
| Библиографическая ссылка | KOCH, W, AN ENHANCER FACTOR DEFECT IN A MUTANT BURKITT-LYMPHOMA CELL-LINE, JOURNAL OF EXPERIMENTAL MEDICINE 167: 1781 (1988). |
| Библиографическая ссылка | LANDSCHULZ, W.H., THE LEUCINE ZIPPER - A HYPOTHETICAL STRUCTURE COMMON TO A NEW CLASS OF DNA-BINDING PROTEINS, SCIENCE 240: 1759 (1988). |
| Библиографическая ссылка | LIN, Y.S., INTERACTION OF A COMMON CELLULAR TRANSCRIPTION FACTOR, ATF, WITH REGULATORY ELEMENTS IN BOTH E1A-INDUCABLE AND CYCLIC AMP-INDUCIBLE PROMOTERS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 3396 (1988). |
| Библиографическая ссылка | LIOU, H.C., DISTINCT CLONED CLASS-II MHC DNA-BINDING PROTEINS RECOGNIZE THE X-BOX TRANSCRIPTION ELEMENT, SCIENCE 242: 69 (1988). |
| Библиографическая ссылка | LIOU, H.C., unpublished data. |
| Библиографическая ссылка | MIWA, K, SEQUENCE-SPECIFIC INTERACTIONS OF NUCLEAR FACTORS WITH CONSERVED SEQUENCES OF HUMAN CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX GENES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 4939 (1987). |
| Библиографическая ссылка | NAKABEPPU, Y, DNA-BINDING ACTIVITIES OF 3 MURINE JUN PROTEINS - STIMULATION BY FOS, CELL 55: 907 (1988). |
| Библиографическая ссылка | REITH, W, CONGENITAL IMMUNODEFICIENCY WITH A REGULATORY DEFECT IN MHC CLASS-II GENE-EXPRESSION LACKS A SPECIFIC HLA-DR PROMOTER BINDING-PROTEIN, RF-X, CELL 53: 897 (1988). |
| Библиографическая ссылка | SCHUERMANN, M, THE LEUCINE REPEAT MOTIF IN FOS PROTEIN MEDIATES COMPLEX-FORMATION WITH JUN AP-1 AND IS REQUIRED FOR TRANSFORMATION, CELL 56: 507 (1989). |
| Библиографическая ссылка | SHERMAN, P.A., CLASS-II BOX CONSENSUS SEQUENCES IN THE HLA-DR-ALPHA GENE - TRANSCRIPTIONAL FUNCTION AND INTERACTION WITH NUCLEAR PROTEINS, MOLECULAR AND CELLULAR BIOLOGY 9: 50 (1989). |
| Библиографическая ссылка | SHERMAN, P.A., UPSTREAM DNA-SEQUENCES REQUIRED FOR TISSUE-SPECIFIC EXPRESSION OF THE HLA-DR-ALPHA GENE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 4254 (1987). |
| Библиографическая ссылка | SINGH, H, MOLECULAR-CLONING OF AN ENHANCER BINDING-PROTEIN - ISOLATION BY SCREENING OF AN EXPRESSION LIBRARY WITH A RECOGNITION SITE DNA, CELL 52: 415 (1988). |
| Библиографическая ссылка | SLOAN, J.H., CONSERVED UPSTREAM SEQUENCES OF HUMAN CLASS-II MAJOR HISTOCOMPATIBILITY GENES ENHANCE EXPRESSION OF CLASS-II GENES IN WILD-TYPE BUT NOT MUTANT B-CELL LINES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85: 8186 (1988). |
| Библиографическая ссылка | STIMAC, E, unpublished data. |
| Библиографическая ссылка | STRUHL, K, THE DNA-BINDING DOMAINS OF THE JUN ONCOPROTEIN AND THE YEAST GCN4 TRANSCRIPTIONAL ACTIVATOR PROTEIN ARE FUNCTIONALLY HOMOLOGOUS, CELL 50: 841 (1987). |
| Библиографическая ссылка | VANEWIJK, W, COMPARTMENTALIZATION OF MHC CLASS-II GENE-EXPRESSION IN TRANSGENIC MICE, CELL 53: 357 (1988). |
