| Автор | Kitajima, I |
| Автор | Shinohara, T |
| Автор | Bilakovics, J |
| Автор | Brown, DA |
| Автор | Xu, X |
| Автор | Nerenberg, M |
| Дата выпуска | 1992 |
| dc.description | Mice transgenic for the human T cell leukemia virus (HTLV-I) Tax gene develop fibroblastic tumors that express NF-kappa B-inducible early genes. In vitro inhibition of NF-kappa B expression by antisense oligodeoxynucleotides (ODNs) inhibited growth of these culture-adapted Tax-transformed fibroblasts as well as an HTLV-I-transformed human lymphocyte line. In contrast, antisense inhibition of Tax itself had no apparent effect on cell growth. Mice treated with antisense to NF-kappa B ODNs showed rapid regression of transplanted fibrosarcomas. This suggests that NF-kappa B expression may be necessary for the maintenance of the malignant phenotype and provides a therapeutic approach for HTLV-I-associated disease. |
| Формат | application.pdf |
| Издатель | American Association for the Advancement of Science |
| Тема | articles |
| Название | Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B |
| Тип | other |
| Electronic ISSN | 1095-9203 |
| Print ISSN | 0036-8075 |
| Журнал | Science |
| Том | 258 |
| Первая страница | 1792 |
| Последняя страница | 1795 |
| Выпуск | 5089 |
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