| Автор | Bump, NJ |
| Автор | Hackett, M |
| Автор | Hugunin, M |
| Автор | Seshagiri, S |
| Автор | Brady, K |
| Автор | Chen, P |
| Автор | Ferenz, C |
| Автор | Franklin, S |
| Автор | Ghayur, T |
| Автор | Li, P |
| Автор | et, al. |
| Дата выпуска | 1995 |
| dc.description | The baculovirus antiapoptotic protein p35 inhibited the proteolytic activity of human interleukin-1 beta converting enzyme (ICE) and three of its homologs in enzymatic assays. Coexpression of p35 prevented the autoproteolytic activation of ICE from its precursor form and blocked ICE-induced apoptosis. Inhibition of enzymatic activity correlated with the cleavage of p35 and the formation of a stable ICE-p35 complex. The ability of p35 to block apoptosis in different pathways and in distantly related organisms suggests a central and conserved role for ICE-like proteases in the induction of apoptosis. |
| Формат | application.pdf |
| Издатель | American Association for the Advancement of Science |
| Тема | articles |
| Название | Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35 |
| Тип | other |
| Electronic ISSN | 1095-9203 |
| Print ISSN | 0036-8075 |
| Журнал | Science |
| Том | 269 |
| Первая страница | 1885 |
| Последняя страница | 1888 |
| Выпуск | 5232 |
| Библиографическая ссылка | BUMP, N, unpublished data. |
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