A prospective study concerning the driving ability of 41 patients with the diagnosis of Alzheimerʼs disease (AD) was performed. Using a simulated driving test we evaluated the predictive value of the MMSE,ʼ⁴ ADL,5-⁷ and IADL&⁹ to determine the ability of a person with Alzheimerʼs disease to drive. All patients were driving at the time of the evaluation.There was no correlation between driving performance and functional status evaluated by ADL and IADL. When comparing driving performance with cognitive evaluation by MMSE, a significant number of patients with MMSE c 22failed the test, compared to patients with MMSE > 22 (P = 0.01, Fisherʼs exact test).No patient with a MMSE < 20 passed the driving test. The authors recommend that health care professionals who are caring for people with Alzheimerʼs disease with a MMSE of22 or less should request a driving evaluation.