Издательство SAGE Publications по журналам "Journal of Biomolecular Screening"
Отображаемые элементы 1-20 из 147
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(Sage Publications, 1998-04-01)We report the successful miniaturization of a functional cell-based reporter gene assay. Utilizing interleukin-1beta (IL-1/)-induced secreted placental alkaline phosphatase (SPAP)-catalyzed colorimetric readout, we reduced ...
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(Sage Publications, 1997-04-01)A homogenous fluorescent HTS for recombinant human factor VIIa (FVIIa) using soluble tissue factor has been developed in 384-well microplates. In this report we discuss our experiences with assay development, liquid handling ...
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(Sage Publications, 1996-06-01)Simultaneous 96-well pipetting is an integral procedure in high throughput screening (HTS). There are several automated 96-well pipettors in the marketplace today. Inherent to any successful HTS assay is an understanding ...
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(Sage Publications, 1996-04-01)Combinatorial chemistry has opened a new realm of chemical diversity in the search for useful therapeutics as well as the ability to generate chemical libraries of hundreds of thousands to millions of discrete compounds. ...
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(Sage Publications, 1998-03-01)A scintillation proximity assay (SPA) is described, which quantitates the ability of compounds to inhibit the binding interaction of a select phosphopeptide with the tandem SH2 domains of the ZAP-70 protein tyrosine kinase. ...
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(Sage Publications, 1997-06-01)A 96-well enzyme-linked immunosorbent assay was developed to discover compounds that inhibit the binding of the Leu-X-Cys-X-Glu (LXCXE) motif to the retinoblastoma tumor suppressor protein (pRB). The assay uses a ...
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(Sage Publications, 1997-02-01)Binding of a protein at a ligand-modified ion channel can lead to closure or distortion of the channel, resulting in a digital on/off response of the ion flux. This principle could be applied as a strategy for sensor design ...
Отображаемые элементы 1-20 из 147