N-Acetylation Phenotype in Bladder Cancer
Woodhouse, K.W.; Adams, P.C.; Clothier, A.; Mucklow, J.C.; Rawlins, M.D.; Woodhouse, K.W., Wolfson Unit of Clinical Pharmacology, The University, Newcastle upon Tyne; Adams, P.C., Wolfson Unit of Clinical Pharmacology, The University, Newcastle upon Tyne; Clothier, A., Wolfson Unit of Clinical Pharmacology, The University, Newcastle upon Tyne; Mucklow, J.C., Department of Clinical Pharmacology, City General Hospital, Stoke-on-Trent; Rawlins, M.D., Wolfson Unit of Clinical Pharmacology, The University, Newcastle upon Tyne
Журнал:
Human and Experimental Toxicology
Дата:
1982
Аннотация:
1N-acetylation phenotype has been examined in 30 patients with bladder cancer and in 27 controls of similar age.2 59% of controls and 70% of bladder cancer patients were phenotypically 'slow' acetylators. This difference was not significant (P>0.30).3 Within phenotypes, isoniazed half life was similar in controls and bladder cancer patients.4 N-acetylation phenotype is unlikely to be a major determinant in the pathogenesis of bladder cancer in the population studied.
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