| Автор | Leighty, E., G. |
| Автор | Hinderer, R., K. |
| Дата выпуска | 1984 |
| dc.description | The metabolic fate of orally administered <sup>14</sup>C-DNPDA containing 0.028% <sup>14</sup>C-BNA was studied in the Rhesus monkey, and the aqueous solubility of these 2 chemicals was investigated. Monkeys were given doses of 0,10, or 100 mg/kg <sup>14</sup>C-DNPDA via gelatin capsules. Uptake by the blood, tissue distribution, and urine and fecal elimination were monitored for up to 168 hours. In these studies <sup>14</sup>C-BNA was 10 to 15 times more soluble than <sup>14</sup>C-DNPDA. Very low levels of <sup>14</sup>C-DNPDA were observed in the blood, tissues, and urine; most (65–75%) of the parent compound was recovered unchanged in the feces. The blood uptake studies showed that the <sup>14</sup>C-BNA impurity is selectively absorbed over the <sup>14</sup>C-DNPDA. Although it was not possible to completely rule out the metabolic formation of <sup>14</sup>C-BNA, the data suggested that any BNA formed via metabolism is insignificant relative to the contribution of any impurity in the product. |
| Издатель | SAGE Publications |
| Название | N,N′-<sup>14</sup>C-Dinaphthyl-p-Phenylene Diamine Metabolism in the Rhesus Monkey |
| Тип | Journal Article |
| DOI | 10.3109/10915818409009072 |
| Electronic ISSN | 1092-874X |
| Print ISSN | 1091-5818 |
| Журнал | International Journal of Toxicology |
| Том | 3 |
| Первая страница | 43 |
| Последняя страница | 56 |
| Аффилиация | Leighty, E., G., Battelle Columbus Laboratories, 505 King Avenue, Columbus, Ohio 43201. |
| Аффилиация | Hinderer, R., K., BF Goodrich Company 500 South Main Street Akron, OH 44318 |
| Выпуск | 1 |
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| Библиографическая ссылка | Clayson, D. B., and Garner, R. C. (1976). Carcinogenic aromatic amines and related compounds. In: Chemical Carcinogens, ACS Monograph 173, C. E. Searles (ed.). p. 406. |
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